ReviewCurrent genetics2018
SMC complexes orchestrate the mitotic chromatin interaction landscape.
Review in Current genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Progressive chromosome shape changes during cell divisions.EMBO reports · 2025Article
- Review
- Positive Selection Drives the Evolution of the Structural Maintenance of Chromosomes (SMC) Complexes.Genes · 2024Article
- G1-Cyclin2 (Cln2) promotes chromosome hypercondensation in eco1/ctf7 rad61 null cells during hyperthermic stress in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2022Article
- It's all in the numbers: Cohesin stoichiometry.Frontiers in molecular biosciences · 2022Review
- Mitotic chromosomes.Seminars in cell & developmental biology · 2021Review
- Comparison of loop extrusion and diffusion capture as mitotic chromosome formation pathways in fission yeast.Nucleic acids research · 2021Article
- IRX3/5 regulate mitotic chromatid segregation and limb bud shape.Development (Cambridge, England) · 2020Article
- SMC complexes organize the bacterial chromosome by lengthwise compaction.Current genetics · 2020Review
- Promotion of Hyperthermic-Induced rDNA Hypercondensation inGenetics · 2020Article
- Mitotic chromosome organization: General rules meet species-specific variability.Computational and structural biotechnology journal · 2020Review
- Unraveling quiescence-specific repressive chromatin domains.Current genetics · 2019Review
- Meiotic prophase-like pathway for cleavage-independent removal of cohesin for chromosome morphogenesis.Current genetics · 2019Review
- How do cells count multi-copy genes?: "Musical Chair" model for preserving the number of rDNA copies.Current genetics · 2019Review
- Crosstalk between chromatin structure, cohesin activity and transcription.Epigenetics & chromatin · 2019Article
- The chromatin remodeler Chd1 regulates cohesin in budding yeast and humans.Scientific reports · 2019Article
- Recruitment, loading, and activation of the Smc5-Smc6 SUMO ligase.Current genetics · 2019Review
- Condensin action and compaction.Current genetics · 2019Review
- Chromatin architecture and virulence-related gene expression in eukaryotic microbial pathogens.Current genetics · 2019Review
- Epigenetic fates of gene silencing established by heterochromatin spreading in cell identity and genome stability.Current genetics · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Chromatin is a very long DNA-protein complex that controls the expression and inheritance of the genetic information. Chromatin is stored within the nucleus in interphase and further compacted into chromosomes during mitosis. This process, known as chromosome condensation, is essential for faithful segregation of genomic DNA into daughter cells. Condensin and cohesin, members of the structural maintenance of chromosomes (SMC) family, are fundamental for chromosome architecture, both for establishment of chromatin structure in the interphase nucleus and for the formation of condensed chromosomes in mitosis. These ring-shaped SMC complexes are thought to regulate the interactions between DNA strands by topologically entrapping DNA. How this activity shapes chromosomes is not yet understood. Recent high throughput chromosome conformation capture studies revealed how chromatin is reorganized during the cell cycle and have started to explore the role of SMC complexes in mitotic chromatin architecture. Here, we summarize these findings and discuss the conserved nature of chromosome condensation in eukaryotes. We highlight the unexpected finding that condensin-dependent intra-chromosomal interactions in mitosis increase within a distinctive distance range that is characteristic for an organism, while longer and shorter-range interactions are suppressed. This reveals important molecular insight into chromosome architecture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.