ArticleIntensive care medicine2017
Early application of airway pressure release ventilation may reduce the duration of mechanical ventilation in acute respiratory distress syndrome.
Article in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 105 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Use of Airway Pressure ReLease Ventilation in Critically Ill Adults With Moderate-to-severe Acute Respiratory Distress Syndrome
Evaluation of Airway Pressure Release Ventilation on Oxygenation in Acute Respiratory Distress Syndrome in Adult Patients With COVID-19 Pneumonia
Monitorings the Physiological Mechanism of Airway Pressure Release Ventilation(APRV) in Acute Respiratory Distress Syndrome (ARDS) Patients by Electrical Impedance Tomography(EIT)
Effect of Airway Pressure Release Ventilation(APRV) on Right Ventricular Function Assessed by Transthoracic Echocardiography
Effect of Airway Pressure Release Ventilation vs. Low Tidal Volume Ventilation on Right Heart Function in Acute Respiratory Distress Syndrome Patients: a Single-center Randomized Controlled Study
Who cites it
105 citing papers in PubMed, 7 syntheses or guidelines pooled it, 249 citations in OpenAlex.
- Composite outcome measures in high-impact critical care randomised controlled trials: a systematic review.Critical care (London, England) · 2024Pooled it
- Sample size estimation in clinical trials using ventilator-free days as the primary outcome: a systematic review.Critical care (London, England) · 2023Pooled it
- Early spontaneous breathing for acute respiratory distress syndrome in individuals with COVID-19.The Cochrane database of systematic reviews · 2022Pooled it
- Safety, efficacy and biomarkers analysis of mesenchymal stromal cells therapy in ARDS: a systematic review and meta-analysis based on phase I and II RCTs.Stem cell research & therapy · 2022Pooled it
- Impact of differences in acute respiratory distress syndrome randomised controlled trial inclusion and exclusion criteria: systematic review and meta-analysis.British journal of anaesthesia · 2021Pooled it
- Between-trial heterogeneity in ARDS research.Intensive care medicine · 2021Pooled it
- [S3 Guideline Sepsis-prevention, diagnosis, therapy, and aftercare : Long version].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Guideline
- Randomized Feasibility Trial of a Low Tidal Volume-Airway Pressure Release Ventilation Protocol Compared With Traditional Airway Pressure Release Ventilation and Volume Control Ventilation Protocols.Critical care medicine · 2018Trial
- The effect of preemptive airway pressure release ventilation on patients with high risk for acute respiratory distress syndrome: a randomized controlled trial.Brazilian journal of anesthesiology (Elsevier)Trial
- Variable pressure support ventilation vs. biphasic positive airway pressure/airway pressure release ventilation in experimental acute respiratory failure.BMC anesthesiology · 2026Article
- Airway Pressure Release Ventilation with a Time-Controlled Adaptive Ventilation Strategy (APRV-TCAV) Reverses Endotracheal Secretion Movement Compared with Volume-Control Ventilation: A Bench Study.Journal of clinical medicine · 2026Article
- JICS education: mechanical ventilation - physiology, mechanism and modes.Journal of the Intensive Care Society · 2026Review
- Managing Respiratory Failure in Late Pregnancy.Journal of clinical medicine · 2026Review
- Outcome and Oxygenation Response to Airway Pressure Release Ventilation (APRV) Used as a Rescue Strategy for Severe Hypoxemic Respiratory Failure-An Observational Study.Journal of clinical medicine · 2026Article
- Ventilator-induced lung injury: from mechanisms to integrated clinical management.Frontiers in medicine · 2026Review
- Airway pressure release ventilation in acute severe asthma: a case series and physiologic framework.Frontiers in medicine · 2026Article
- Knowledge and practice of airway pressure release ventilation in patients with acute respiratory distress syndrome among ICU nurses and respiratory therapists in China: a multicenter cross-sectional survey.Frontiers in medicine · 2026Article
- Influence of airway pressure release ventilation on pulmonary gas exchange using ventilatory ratio.Frontiers in medicine · 2026Article
- Toward optimal mechanical ventilation of the injured lung: the role of expiratory duration.Critical care (London, England) · 2025Review
- Effects of rescue airway pressure release ventilation on mortality in severe pediatric acute respiratory distress syndrome: a retrospective comparative analysis from India.Acute and critical care · 2025Article
45 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeExperimental animal models of acute respiratory distress syndrome (ARDS) have shown that the updated airway pressure release ventilation (APRV) methodologies may significantly improve oxygenation, maximize lung recruitment, and attenuate lung injury, without circulatory depression. This led us to hypothesize that early application of APRV in patients with ARDS would allow pulmonary function to recover faster and would reduce the duration of mechanical ventilation as compared with low tidal volume lung protective ventilation (LTV).
methodsA total of 138 patients with ARDS who received mechanical ventilation for <48 h between May 2015 to October 2016 while in the critical care medicine unit (ICU) of the West China Hospital of Sichuan University were enrolled in the study. Patients were randomly assigned to receive APRV (n = 71) or LTV (n = 67). The settings for APRV were: high airway pressure (P
resultsCompared with the LTV group, patients in the APRV group had a higher median number of ventilator-free days {19 [interquartile range (IQR) 8-22] vs. 2 (IQR 0-15); P < 0.001}. This finding was independent of the coexisting differences in chronic disease. The APRV group had a shorter stay in the ICU (P = 0.003). The ICU mortality rate was 19.7% in the APRV group versus 34.3% in the LTV group (P = 0.053) and was associated with better oxygenation and respiratory system compliance, lower P
conclusionsCompared with LTV, early application of APRV in patients with ARDS improved oxygenation and respiratory system compliance, decreased P
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.