ArticleWorld journal of surgery2018
Early Versus Delayed Source Control in Open Abdomen Management for Severe Intra-abdominal Infections: A Retrospective Analysis on 111 Cases.
Article in World journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Negative pressure wound therapy for managing the open abdomen in non-trauma patients.The Cochrane database of systematic reviews · 2022Pooled it
- Damage control surgery in non-traumatic abdominal emergencies: prognostic value of SOFA, APACHEII, and Mannheim peritonitis index.Updates in surgery · 2025Article
- Sepsis, Management & Advances in Metabolomics.Nanotheranostics · 2024Review
- Timing of surgical operation for patients with intra-abdominal infection: A systematic review and meta-analysis.World journal of gastrointestinal surgery · 2023Article
- Source control in emergency general surgery: WSES, GAIS, SIS-E, SIS-A guidelines.World journal of emergency surgery : WJES · 2023Review
- Epidemiological Characteristics, Antimicrobial Susceptibility Profile, and Surgical Outcome of Complicated Intra-Abdominal Infection at a Tertiary Hospital in Somalia.International journal of general medicine · 2022Article
- Rate of stoma formation following damage-control surgery for severe intra-abdominal sepsis: a single-centre consecutive case series.BJS open · 2021Article
- What Do We Know about Early Management of Sepsis and Septic Shock in Polish Hospitals? A Questionnaire Study.Healthcare (Basel, Switzerland) · 2021Article
- Lessons Learned in 11 Years of Experience With Open Abdomen Treatment With Negative-Pressure Therapy for Various Abdominal Emergencies.Frontiers in surgery · 2021Article
- Current progress of source control in the management of intra-abdominal infections.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2020Review
- Time to clearance of abdominal septic focus and mortality in patients with sepsis.Revista Brasileira de terapia intensiva · 2020Observational
- Bloodstream infections in critically ill patients: an expert statement.Intensive care medicine · 2020Article
- Rules of anti-infection therapy for sepsis and septic shock.Chinese medical journal · 2019Review
- Observational
- Getting the invite list right: a discussion of sepsis severity scoring systems in severe complicated intra-abdominal sepsis and randomized trial inclusion criteria.World journal of emergency surgery : WJES · 2018Article
- Sepsis in a Panorama: What the Cardiovascular Physician Should Know.Methodist DeBakey cardiovascular journalReview
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTime to source control plays a determinant prognostic role in patients having severe intra-abdominal infections (IAIs). Open abdomen (OA) management became an effective treatment option for peritonitis. Aim of this study was to analyze the correlation between time to source control and outcome in patients presenting with abdominal sepsis and treated by OA.
methodsWe retrospectively analyzed 111 patients affected by abdominal sepsis and treated with OA from May 2007 to May 2015. Patients were classified according to time interval from first patient evaluation to source control. The end points were intra-hospital mortality and primary fascial closure rate.
resultsThe in-hospital mortality rate was 21.6% (24/111), and the primary fascial closure rate was 90.9% (101/111). A time to source control ≥6 h resulted significantly associated with a poor prognosis and a lower fascial closure rate (mortality 27.0 vs 9.0%, p = 0.04; primary fascial closure 86 vs 100%, p = 0.02). We observed a direct increase in mortality (and a reduction in closure rate) for each 6-h delay in surgery to source control.
conclusionEarly source control using OA management significantly improves outcome of patients with severe IAIs. This damage control approach well fits to the treatment of time-related conditions, particularly in case of critically ill patients.
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