Evidence map›Paper›PMID 28936622›Full record

SynthesisEuropean child & adolescent psychiatry2018

Prevalence of psychopathology in bipolar high-risk offspring and siblings: a meta-analysis.

Phoebe Lau, David J Hawes, Caroline Hunt, Andrew Frankland, Gloria Roberts, Philip B Mitchell

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in European child & adolescent psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Phoebe LauSchool of Psychology, Brain and Mind Centre, University of Sydney, Camperdown, Sydney, NSW, Australia.
David J HawesSchool of Psychology, Brain and Mind Centre, University of Sydney, Camperdown, Sydney, NSW, Australia. david.hawes@sydney.edu.au.
Caroline HuntSchool of Psychology, Brain and Mind Centre, University of Sydney, Camperdown, Sydney, NSW, Australia.
Andrew FranklandSchool of Psychiatry, University of New South Wales, Black Dog Institute, Randwick, Sydney, NSW, Australia.
Gloria RobertsSchool of Psychiatry, University of New South Wales, Black Dog Institute, Randwick, Sydney, NSW, Australia.
Philip B MitchellSchool of Psychiatry, University of New South Wales, Black Dog Institute, Randwick, Sydney, NSW, Australia.
University of Sydney · AUBlack Dog Institute · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This meta-analysis aimed to update existing data on the comparison of prevalence rates of psychopathology primarily among offspring with at least one parent with bipolar disorder (BD) and offspring of parents without psychiatric illness. Seventeen studies were derived from a systematic search of PsychInfo, Medline, Scopus and Embase. Inclusion criteria were use of a control offspring group, standardized diagnostic procedures and reporting of clear frequency data. Risk of psychopathology was estimated by aggregating frequency data from selected studies. Compared to control offspring, high-risk BD offspring are nine times more likely to have a bipolar-type disorder, almost two and a half times more likely to develop a non-BD affective disorder and over two times more likely to develop at least one anxiety disorder. High-risk offspring also showed a significant increased risk of other non-mood psychopathology such as attention deficit hyperactivity disorder (ADHD), any type of behavioral disorder and substance use disorder (SUDs). Risk of developing a broad range of affective and non-affective psychopathology is significantly higher in high-risk BD offspring. Identifying clinical presentations of this genetically high-risk cohort is important in establishing appropriate preventative treatment.

Indexed as

AdolescentBipolar DisorderChildFemaleHumansMalePrevalencePsychopathologyRisk FactorsSiblingsAt-riskBipolar disorderChildrenMeta-analysisOffspringPsychopathology

Identifiers

PMID28936622
OpenAlexW2759941158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.