ArticleComputing in cardiology2016
Patient-Specific Time-Varying Association between Spatial and Temporal Variability in Repolarization and High Sensitivity Troponin I.
Article in Computing in cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Temporal variability of T-wave morphology and risk of sudden cardiac death in patients with coronary artery disease.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We hypothesized that the patient-specific time-varying changes in the spatial and temporal variability in cardiac repolarization (quantified by spatial TT' angle), and in myocardial injury (measured by high sensitivity troponin I, hsTnI), are independently associated with each other. Spatial TT' angle on resting 12-lead ECG (transformed to vectorcardiogram) and hsTnI were measured simultaneously every 3 hours during a 12-hour observation period in a prospective cohort of emergency department patients (n=379; age 57.8±13.2y; 54% female, 64% black), diagnosed with acute coronary syndrome (ACS; n=28), acute decompensated heart failure (ADHF; n=35), or an acute non-cardiac condition (n=316). High (above median) HsTnI in ACS was characterized by significantly larger TT' angle (12±8 vs 5±2 degrees; P=0.01) 12 hours after admission, but not earlier. In adjusted multinomial logit model, spatial TT' angle was associated with ADHF (Relative Risk Ratio 6.24 (95%CI 1.32-29.57; P=0.021), but not ACS. After full adjustment for confounders in random-effect linear regression, a 10-fold increase in hsTnI in a specific study participant was associated with 1.05 (95%CI 0.19 - 1.92) degrees increase in spatial TT' angle. Longitudinal association of hsTnI and TT' angle was especially prominent in patients with acute non-cardiac conditions, but not in ACS or ADHF.
Identifiers
28936465PMC5604480W2592841437What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.