Evidence map›Paper›PMID 28936427›Full record

ArticleJournal of molecular and engineering materials2016

Controlling the Biomimetic Implant Interface: Modulating Antimicrobial Activity by Spacer Design.

Cate Wisdom, Sarah Kay VanOosten, Kyle W Boone, Dmytro Khvostenko, Paul M Arnold, Malcolm L Snead, Candan Tamerler

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular and engineering materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Harnessing biomolecules for bioinspired dental biomaterials.Journal of materials chemistry. B · 2020
    Review
  10. Article
  11. Article
  12. Antimicrobial Peptide-Polymer Conjugates for Dentistry.ACS applied polymer materials · 2020
    Article
  13. Threats to adhesive/dentin interfacial integrity and next generation bio-enabled multifunctional adhesives.Journal of biomedical materials research. Part B, Applied biomaterials · 2019
    Review
  14. Review
  15. Article
  16. Article
  17. Peptide Mediated Antimicrobial Dental Adhesive System.Applied sciences (Basel, Switzerland) · 2019
    Article
  18. Self-assembling antimicrobial peptides on nanotubular titanium surfaces coated with calcium phosphate for local therapy.Materials science & engineering. C, Materials for biological applications · 2019
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Cate WisdomBioengineering Program, University of Kansas, 3135A Learned Hall, 1530 W 15th Street Lawrence, Kansas 66045, USA.
Sarah Kay VanOostenBioengineering Program, University of Kansas, 3135A Learned Hall, 1530 W 15th Street Lawrence, Kansas 66045, USA.
Kyle W BooneBioengineering Program, University of Kansas, 3135A Learned Hall, 1530 W 15th Street Lawrence, Kansas 66045, USA.
Dmytro KhvostenkoBioengineering Research Center (BERC), University of Kansas, 3138 Learned Hall, 1530 W 15th Street Lawrence, Kansas 66045, USA, dmytro.khvostenko@ku.edu.
Paul M ArnoldDepartment of Neurosurgery, University of Kansas Medical Center, 3901 Rainbow Boulevard Kansas City, Kansas 66160, USA, parnold@kumc.edu.
Malcolm L SneadCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry of USC, The University of Southern California CSA 142, 2250 Alcazar Street Los Angeles, CA 90033, USA, mlsnead@usc.edu.
Candan TamerlerMechanical Engineering Department and BERC, University of Kansas, 3138 Learned Hall, 1530 W 15th Street Lawrence, Kansas 66045, USA.
University of Kansas Medical Center · USUniversity of Southern California · US

Funding

Peptide-Polymer Engineering Dentin/Adhesive Interfacial Bond IntegrityR01DE025476 · NIDCR · UNIVERSITY OF KANSAS LAWRENCE · PI SPENCER, PAULETTE, TAMERLER-BEHAR, CANDAN · 2015 to 2024
$3.2M
Peptide Enabled Self Assembled Reconfigurable Implant CoatingsR21AR062249 · NIAMS · UNIVERSITY OF WASHINGTON · PI TAMERLER-BEHAR, CANDAN · 2012 to 2013
$363k
Inducing Dental Implant Bone Formation to Treat Peri-implantitisR43DE027306 · NIDCR · INTEGRATED, LLC · PI SNEAD, MALCOLM L. · 2017 to 2017
$225k
NIAMS NIH HHS R21 AR062249NIDCR NIH HHS R01 DE025476NIDCR NIH HHS R43 DE027306
6 · The paper itself

Abstract

Surgical site infection is a common cause of post-operative morbidity, often leading to implant loosening, ultimately requiring revision surgery, increased costs and worse surgical outcomes. Since implant failure starts at the implant surface, creating and controlling the bio-material interface will play a critical role in reducing infection while improving host cell-to-implant interaction. Here, we engineered a biomimetic interface based upon a chimeric peptide that incorporates a titanium binding peptide (TiBP) with an antimicrobial peptide (AMP) into a single molecule to direct binding to the implant surface and deliver an antimicrobial activity against

Indexed as

antimicrobial peptidesbiocoatingbio-nanomaterialimplantsInfectionsinterfacepeptide designstructural analysis

Identifiers

PMID28936427
PMCPMC5604879
OpenAlexW2464864096

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.