Evidence map›Paper›PMID 28936407›Full record

ReviewJournal of clinical and translational hepatology2017

Current Modalities of Fibrosis Assessment in Non-alcoholic Fatty Liver Disease.

Mark Cc Cheah, Arthur J McCullough, George Boon-Bee Goh

Registry-linked trialOpen access · diamondAbstract readReview
In one paragraph

Review in Journal of clinical and translational hepatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05301231 (Omics-based Predictors of NAFLD/Potential NASH), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05301231 unknown statusnot on this mapstarted 2022, after this paper: background citation

Omics-based Predictors of NAFLD/Potential NASH: A New Era Towards Valid and Reliable Non-invasive Diagnosis and Personalized Therapy

Typeobservational_patient_registrySponsorNational Research Centre, EgyptRan2022 to 2024Enrolled450ConditionsNon-Alcoholic Fatty Liver Disease, Non Alcoholic SteatohepatitisArmsGenomics (DNA Extraction), Epi-genomics, Proteomics (Glycoproteomics), Salivary Metabolomics, Individualized counselling for behavioural modification
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

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  14. [Histopathological evaluation of cirrhosis reversal].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Mark Cc CheahDepartment of Gastroenterology & Hepatology, Singapore General Hospital, Singapore.
Arthur J McCulloughDepartment of Gastroenterology, Cleveland Clinic, Ohio, USA.
George Boon-Bee GohDepartment of Gastroenterology & Hepatology, Singapore General Hospital, Singapore.
Singapore General Hospital · SGCleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a burgeoning global health concern. In the subset of NAFLD patients with non-alcoholic steatohepatitis (NASH), the presence of significant fibrosis at index assessment is associated with poor prognosis and increased mortality. Hence, there is a growing need to accurately assess and stage fibrosis. Liver biopsy, the current gold standard, has limitations with sampling error and is invasive, with associated inherent risk. This has led to a host of non-invasive means of assessing fibrosis, which has garnered relevance in a disease that requires serial assessment of fibrosis longitudinally over time. This review discusses, comprehensively, the various tools available to the clinician for the assessment of fibrosis, including the various scoring systems used in liver biopsy, the non-invasive means of serum biomarkers, such as the highly-validated NAFLD fibrosis score, and the imaging-based modalities, such as transient elastography and magnetic resonance elastography.

Indexed as

Fibrosis assessmentModalitiesNAFLD

Identifiers

PMID28936407
PMCPMC5606972
OpenAlexW2701978336

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.