ArticleChemical science2016
Targeted anion transporter delivery by coiled-coil driven membrane fusion.
Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Lipid-Based Nanoparticle Functionalization with Coiled-Coil Peptides forAccounts of chemical research · 2024Article
- Molecular Machines For The Control Of Transmembrane Transport.Journal of the American Chemical Society · 2023Review
- Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration.ACS nano · 2023Article
- Dynamic Fusion of Nucleic Acid Functionalized Nano-/Micro-Cell-Like Containments: From Basic Concepts to Applications.ACS nano · 2023Review
- SNARE Modulators and SNARE Mimetic Peptides.Biomolecules · 2022Review
- Supramolecular chemistry in lipid bilayer membranes.Chemical science · 2021Review
- Engineering of stimuli-responsive lipid-bilayer membranes using supramolecular systems.Nature reviews. Chemistry · 2021Review
- Boosting Anion Transport Activity of Diamidocarbazoles by Electron Withdrawing Substituents.Frontiers in chemistry · 2021Article
- Controlled Peptide-Mediated Vesicle Fusion Assessed by Simultaneous Dual-Colour Time-Lapsed Fluorescence Microscopy.Scientific reports · 2020Article
- Apoptosis-inducing activity of a fluorescent barrel-rosette MChemical science · 2020Article
- Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs.Chemical science · 2019Article
- Chemical communication in spatially organized protocell colonies and protocell/living cell micro-arrays.Chemical science · 2019Article
- Anthracene Bisureas as Powerful and Accessible Anion Carriers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Modified mixed nanomicelles with collagen peptides enhanced oral absorption of Cucurbitacin B: preparation and evaluation.Drug delivery · 2018Article
- A flow cytometry assay to quantify intercellular exchange of membrane components.Chemical science · 2017Article
- A Coiled-Coil Peptide Shaping Lipid Bilayers upon Fusion.Biophysical journal · 2016Article
- Drug Delivery via Cell Membrane Fusion Using Lipopeptide Modified Liposomes.ACS central science · 2016Article
- Geometry of the Contact Zone between Fused Membrane-Coated Beads Mimicking Cell-Cell Fusion.Biophysical journal · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
Abstract
Synthetic anion transporters (anionophores) have potential as biomedical research tools and therapeutics. However, the efficient and specific delivery of these highly lipophilic molecules to a target cell membrane is non-trivial. Here, we investigate the delivery of a powerful anionophore to artificial and cell membranes using a coiled-coil-based delivery system inspired by SNARE membrane fusion proteins. Incorporation of complementary lipopeptides into the lipid membranes of liposomes and cell-sized giant unilamellar vesicles (GUVs) facilitated the delivery of a powerful anionophore into GUVs, where its anion transport activity was monitored in real time by fluorescence microscopy. Similar results were achieved using live cells engineered to express a halide-sensitive fluorophore. We conclude that coiled-coil driven membrane fusion is a highly efficient system to deliver anionophores to target cell membranes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.