ArticleFrontiers in psychiatry2017
Hypothermia due to Antipsychotic Medication: A Systematic Review.
Article in Frontiers in psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Treatment of Early-Onset Specified and Unspecified Bipolar Disorders: A Systematic Review and Strategies for Identifying and Managing a Thermally Dysregulated Subtype in Children.Acta psychiatrica Scandinavica · 2025Pooled it
- Risperidone-induced severe hypothermia in an elderly woman with possible prior quetiapine-associated hypothermia tolerating aripiprazole: A case report and literature review.The mental health clinician · 2026Article
- Acute hypothermia induced by valproic acid.Proceedings (Baylor University. Medical Center) · 2026Article
- Antipsychotic-Associated Hypothermia With Bradycardia and QT Prolongation in an Older Adult.Cureus · 2026Article
- A Rare Case of Hypothermia Due to Quetiapine Use.Cureus · 2026Article
- Mortality risk due to non-optimum temperatures by cause of death, age, and sex: a multi-country time-series study.EClinicalMedicine · 2026Article
- Approach to Low Body Temperature or Mild Hypothermia in the Geriatric Population: A Narrative Review.Journal of clinical medicine research · 2026Review
- Recurrent hypothermia associated with atypical antipsychotics: a diagnostic challenge in a medically complex patient.Archive of clinical cases · 2026Article
- Histological and Immunohistochemical Evidence in Hypothermia-Related Death: An Experimental Study.International journal of molecular sciences · 2025Article
- Synergistic rescue of temperature-sensitive p53 mutants by hypothermia and arsenic trioxide.Molecular carcinogenesis · 2024Article
- Article
- Neural cell-types and circuits linking thermoregulation and social behavior.Neuroscience and biobehavioral reviews · 2024Review
- The future of artificial hibernation medicine: protection of nerves and organs after spinal cord injury.Neural regeneration research · 2024Review
- Identifying Risk Factors for Hospitalization with Behavioral Health Disorders and Concurrent Temperature-Related Illness in New York State.International journal of environmental research and public health · 2022Article
- Olanzapine-Induced Therapeutic Hypothermia Attenuates Renal Injury in Rats after Asphyxial Cardiac Arrest and Resuscitation.Antioxidants (Basel, Switzerland) · 2022Article
- Article
- Housing Temperature Influences Atypical Antipsychotic Drug-Induced Bone Loss in Female C57BL/6J Mice.JBMR plus · 2021Article
- Perioperative Hypothermia-A Narrative Review.International journal of environmental research and public health · 2021Review
- A case report of acute hypothermia during initial inpatient clozapine titration with review of current literature on clozapine-induced temperature dysregulations.BMC psychiatry · 2020Review
- Severe hypothermia, bradycardia and cardiac arrest in association with risperidone.BMJ case reports · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypothermia is a rare, but potentially fatal adverse effect of antipsychotic drug (APD) use. Although the opposite condition,
objectiveThis study aimed to review the literature on hypothermia in the context of APD use, and formulate implications for research and clinical care.
methodsA systematic search was made in PubMed and Ovid Medline.
resultsThe literature search yielded 433 articles, including 57 original case descriptions of hypothermia developed during APD use with non-toxic plasma levels. All cases together indicate that the risk of developing hypothermia is highest during the 7 days following initiation, or increase in dosage, of APDs, especially in the presence of additional predisposing factors, such as advanced age, exposure to cold, adjuvant use of benzodiazepines, and (subclinical) hypothyroidism. In addition, data derived from drug-monitoring agencies suggest that the prevalence of APD-related hypothermia is at least 10 times higher than suggested by the literature.
conclusionWe conclude that health-care professionals need to monitor the body temperature of patients starting with (an increased dose of) APDs for a duration of 7-10 days to prevent hypothermia, especially in the presence of multiple risk factors. Moreover, systematic studies are needed to establish the actual prevalence of APD-related hypothermia as well as the relative risk for individual APDs.
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