ArticleScientific reports2017
Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Exacerbated expansive vascular remodeling due to disturbed flow in male mice overexpressing protein disulfide isomerase-A1.Physiological reports · 2026Article
- S2P-modified PLGA bifunctional nanodrug: inhibiting vascular senescence and foam cell formation for atherosclerosis treatment.Journal of nanobiotechnology · 2026Article
- Traumatic vessel injuries initiating hemostasis generate high shear conditions.Blood advances · 2022Article
- Imaging the Local Nonlinear Viscoelastic Properties of Soft Tissues: Initial Validation and Expected Benefits.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Investigation of Wall Shear Stress in Cardiovascular Research and in Clinical Practice-From Bench to Bedside.International journal of molecular sciences · 2021Review
- Shear Induced Non-Linear Elasticity Imaging: Elastography for Compound Deformations.IEEE transactions on medical imaging · 2020Article
- Label-free photoacoustic and ultrasound imaging for murine atherosclerosis characterization.APL bioengineering · 2020Article
- Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling.Journal of the American Heart Association · 2020Article
- Article
- Nonlinear Shear Modulus Estimation With Bi-Axial Motion Registered Local Strain.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2019Article
- Strain-selective efficacy of sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains.British journal of pharmacology · 2019Article
- Visualizing Angle-Independent Principal Strains in the Longitudinal View of the Carotid Artery: Phantom and In Vivo Evaluation.Ultrasound in medicine & biology · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Increased arterial thickness measured with ultrasound correlates with future cardiovascular events, but conventional ultrasound imaging techniques cannot distinguish between intima, media, or atherosclerotic plaque in the carotid artery. In this work, we evaluated how well vascular elastography can detect intimal changes in a mouse model of carotid remodeling. We ligated the left external and internal branches of the carotid artery of male FVB mice and performed sham operations for 2 weeks. High-resolution ultrasound imaging accurately detected lower blood velocities and low blood volume flow in the carotid arteries after ligation in FVB mice. However, ultrasound could not detect differences in the carotid wall even at 2 weeks post-surgery. The Young's modulus was measured based on displacements of the carotid artery wall, and Young's modulus was 2-fold greater in shams at 1 week post ligation, and 3-fold greater 2 weeks after ligation. Finally, the higher Young's modulus was most associated with higher intimal thickness but not medial or adventitial thickness as measured by histology. In conclusion, we developed a robust ultrasound-based elastography method for early detection of intimal changes in small animals.
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