Evidence map›Paper›PMID 28935971›Full record

ArticleScientific reports2017

Prevalence of chronic hepatitis B and status of HBV care among rural women who planned to conceive in China.

Yuanyuan Wang, Hong Zhou, Long Zhang, Qiuyue Zhong, Qiaomei Wang, Haiping Shen, Man Zhang, Yanjie Huang, Anqi Wang, Kenrad Nelson and 14 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Entecavir for children and adults with chronic hepatitis B.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Pooled it
  3. Guideline
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Viral hepatitis and pregnancy.Nature reviews. Gastroenterology & hepatology · 2021
    Review
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 7 institutions in 2 countries.

Yuanyuan WangNational Research Institute for Family Planning, Beijing, China.
Hong ZhouEnvironmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China.
Long ZhangEnvironmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China.
Qiuyue ZhongDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Qiaomei WangDepartment of Maternal and Child Health, National Health and Family Planning Commission of the PRC, Beijing, China.
Haiping ShenDepartment of Maternal and Child Health, National Health and Family Planning Commission of the PRC, Beijing, China.
Man ZhangCenter for Clinical Laboratory, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Yanjie HuangEnvironmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China.
Anqi WangDepartment of Child, Adolescent and Women's Health, School of Public Health, Peking University, Beijing, China.
Kenrad NelsonDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Yiping ZhangDepartment of Maternal and Child Health, National Health and Family Planning Commission of the PRC, Beijing, China.
Donghai YanDepartment of Maternal and Child Health, National Health and Family Planning Commission of the PRC, Beijing, China.
Zuoqi PengNational Research Institute for Family Planning, Beijing, China.
Ya ZhangNational Research Institute for Family Planning, Beijing, China.
Xiaona XinNational Research Institute for Family Planning, Beijing, China.
Hongguang ZhangNational Research Institute for Family Planning, Beijing, China.
Jun ZhaoNational Research Institute for Family Planning, Beijing, China.
Yan WangNational Research Institute for Family Planning, Beijing, China.
Ying YangNational Research Institute for Family Planning, Beijing, China.
Yuan HeNational Research Institute for Family Planning, Beijing, China.
Jihong XuNational Research Institute for Family Planning, Beijing, China.
Xiaoli LiuDepartment of Child, Adolescent and Women's Health, School of Public Health, Peking University, Beijing, China.
Yan WangEnvironmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China. wangyan@bjmu.edu.cn.
Xu MaNational Research Institute for Family Planning, Beijing, China. NFPCC_ma@163.com.
Tianjin Municipal Research Institute for Family Planning · CNPeking University · CNJohns Hopkins University · USNational Health and Family Planning Commission · CNBeijing Shijitan Hospital · CNHarvard University · USPeking Union Medical College Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Globally, one third of prevalent chronic hepatitis B (CHB) virus infection (HBV) occurred in China. Assessing the prevalence of CHB infesction and status of HBV-related services among pre-conception women will provide insight into risks of mother to child transmission (MTCT). A cross-sectional analysis of data from the National Free Pre-pregnancy Checkups (NFPC) program in 2010-2014 was conducted. A standardized questionnaire which collected demographic information and enzyme-linked immunosorbent assays (ELISA) which tested serological HBV markers were applied. A total of 16,051,850 rural women aged 15-49 years were included. 5.2% of women were infected with CHB, among whom, 28.6% were also hepatitis B e antigen (HBeAg) positive. The most CHB concentrated places were distributed in southeastern coastal provinces. Women born after 1992 did not experience a higher level of vaccine-induced immunity compared to those born before 1992. Nine in ten rural women with CHB were not aware of their HBV status and a very small proportion of women (0.22%) had received antiviral treatment. Our data demonstrated an overall high-intermediate burden of CHB. Heterogeneity of geographic distribution, high proportion of HBeAg, insufficient awareness of HBV status, and low access to HBV treatment are challenges for preventing the MTCT.

Indexed as

AdolescentAdultAntiviral AgentsChinaCross-Sectional StudiesFemaleFertilizationGeographyHepatitis B, ChronicHepatitis B virusHumansMiddle AgedPregnancyPregnancy Complications, InfectiousPrevalenceRural PopulationAntiviral Agents

Identifiers

PMID28935971
PMCPMC5608955
OpenAlexW2755023460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.