ArticleNature communications2017
Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 104 citations in OpenAlex.
- The transcription factor ZmMYB3R targets CYCB1;2 to modulate maize drought tolerance.The Plant journal : for cell and molecular biology · 2026Article
- CmDREBa regulates the perennial growth habit of chrysanthemum in response to prolonged chilling.Nature communications · 2026Article
- Regulatory Roles of MYB Transcription Factors in Root Barrier Under Abiotic Stress.Plants (Basel, Switzerland) · 2026Review
- MYB gene from Endocarpon pusillum regulates growth and development and enhances drought tolerance in creeping bentgrass (Agrostis stolonifera L.).BMC plant biology · 2025Article
- Transcriptional signatures associated with waterlogging stress responses and aerenchyma formation in barley root tissue.Annals of botany · 2025Article
- Recruitment, rewiring and deep conservation in flowering plant gene regulation.Nature plants · 2025Article
- Article
- SUPPRESOR OF GAMMA RESPONSE 1 promotes early onset of endoreplication upon DNA double-strand breaks by inducing CCS52A1 expression in Arabidopsis roots.Journal of plant research · 2025Article
- Functional conservation and divergence of arabidopsis VENOSA4 and human SAMHD1 in DNA repair.Heliyon · 2025Article
- The lowdown on breakdown: Open questions in plant proteolysis.The Plant cell · 2024Review
- The MYB family and their response to abiotic stress in ginger (Zingiber officinale Roscoe).BMC genomics · 2024Article
- Mechanistic insights into DNA damage recognition and checkpoint control in plants.Nature plants · 2024Review
- Molecular markers in cell cycle visualisation during development and stress conditions inQuantitative plant biology · 2024Article
- Jasmonates, gibberellins, and powdery mildew modify cell cycle progression and evoke differential spatiotemporal responses along the barley leaf.Journal of experimental botany · 2024Article
- The interplay between cell wall integrity and cell cycle progression in plants.Plant molecular biology · 2023Review
- KNO1-mediated autophagic degradation of the Bloom syndrome complex component RMI1 promotes homologous recombination.The EMBO journal · 2023Article
- SUPPRESSOR OF GAMMA RESPONSE 1 plays rice-specific roles in DNA damage response and repair.Plant physiology · 2023Article
- How Do Plants Cope with DNA Damage? A Concise Review on the DDR Pathway in Plants.International journal of molecular sciences · 2023Review
- Characterization of Transcriptome Dynamics during Early Fruit Development in Olive (International journal of molecular sciences · 2023Article
- Genome editing of SlMYB3R3, a cell cycle transcription factor gene of tomato, induces elongated fruit shape.Journal of experimental botany · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inhibition of cell division is an active response to DNA damage that enables cells to maintain genome integrity. However, how DNA damage arrests the plant cell cycle is largely unknown. Here, we show that the repressor-type R1R2R3-Myb transcription factors (Rep-MYBs), which suppress G2/M-specific genes, are required to inhibit cell division in response to DNA damage. Knockout mutants are resistant to agents that cause DNA double-strand breaks and replication stress. Cyclin-dependent kinases (CDKs) can phosphorylate Rep-MYBs in vitro and are involved in their proteasomal degradation. DNA damage reduces CDK activities and causes accumulation of Rep-MYBs and cytological changes consistent with cell cycle arrest. Our results suggest that CDK suppressors such as CDK inhibitors are not sufficient to arrest the cell cycle in response to DNA damage but that Rep-MYB-dependent repression of G2/M-specific genes is crucial, indicating an essential function for Rep-MYBs in the DNA damage response.Inhibition of cell division maintains genome integrity in response to DNA damage. Here Chen et al. propose that DNA damage causes cell cycle arrest in the Arabidopsis root via Rep-MYB transcription factor-mediated repression of G2/M-specific gene expression in response to reduced cyclin-dependent kinase activity.
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