Evidence map›Paper›PMID 28935892›Full record

ArticleNature communications2017

Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP.

Yiguo Shen, David Kapfhamer, Angela M Minnella, Ji-Eun Kim, Seok Joon Won, Yanting Chen, Yong Huang, Ley Hian Low, Stephen M Massa, Raymond A Swanson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.

  1. Pooled it
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  13. NADProgress in orthodontics · 2025
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yiguo ShenDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.
David KapfhamerDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.
Angela M MinnellaDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.
Ji-Eun KimDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.
Seok Joon WonDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.
Yanting ChenDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.
Yong HuangDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.
Ley Hian LowDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.
Stephen M MassaDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.
Raymond A SwansonDepartment of Neurology, University of California, San Francisco, CA, 94143, USA. Raymond.Swanson@ucsf.edu.
University of California, San Francisco · USSan Francisco VA Medical Center · US

Funding

Mechanisms of PARP and PARG mediated cell deathR01NS041421 · NINDS · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI SWANSON, RAYMOND A · 2002 to 2014
$2.9M
Regulatory Control of Glutamate - Induced Superoxide Production [Admin Supplement]R01NS081149 · NINDS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI SWANSON, RAYMOND A · 2012 to 2016
$1.7M
Trk Ligands for Treatment of Traumatic Brain InjuryI01BX000267 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI MASSA, STEPHEN M. · 2009 to 2018
–
BLRD VA I01 BX000267NINDS NIH HHS R01 NS041421NINDS NIH HHS R01 NS081149
6 · The paper itself

Abstract

The innate inflammatory response contributes to secondary injury in brain trauma and other disorders. Metabolic factors such as caloric restriction, ketogenic diet, and hyperglycemia influence the inflammatory response, but how this occurs is unclear. Here, we show that glucose metabolism regulates pro-inflammatory NF-κB transcriptional activity through effects on the cytosolic NADH:NAD

Indexed as

Immunity, InnateTranscription, GeneticAlcohol OxidoreductasesAnimalsBinding SitesCo-Repressor ProteinsDimerizationDNA-Binding ProteinsEnergy MetabolismGlucoseMacrophagesMiceMicrogliaNADNF-kappa Bp300-CBP-Associated FactorAlcohol OxidoreductasesCo-Repressor ProteinsCtbp2 protein, mouseC-terminal binding proteinDNA-Binding ProteinsGlucoseNADNF-kappa Bp300-CBP-Associated Factorp300-CBP Transcription FactorsPhosphoproteins

Identifiers

PMID28935892
PMCPMC5608947
OpenAlexW2755129098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.