Evidence map›Paper›PMID 28935838›Full record

Trial reportJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

Decreased Pretreatment Amygdalae Serotonin Transporter Binding in Unipolar Depression Remitters: A Prospective PET Study.

Mala R Ananth, Christine DeLorenzo, Jie Yang, J John Mann, Ramin V Parsey

Erratum issuedOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Prediction of lithium treatment response in bipolar depression using 5-HTT and 5-HTEuropean journal of nuclear medicine and molecular imaging · 2020
    Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Promising Neuroimaging Biomarkers in Depression.Psychiatry investigation · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mala R AnanthDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York mala.ananth@stonybrook.edu.
Christine DeLorenzoPsychiatry, Stony Brook University, Stony Brook, New York.
Jie YangFamily, Population and Preventative Medicine, Stony Brook University, Stony Brook, New York.
J John MannFamily, Population and Preventative Medicine, Stony Brook University, Stony Brook, New York.
Ramin V ParseyPsychiatry, Stony Brook University, Stony Brook, New York.
Stony Brook University · USColumbia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Major depressive disorder (MDD) is a debilitating condition that affects over 14 million Americans. Remission occurs only in a minority of individuals after first-line antidepressant treatment (∼35%); predictors of treatment outcome are therefore needed. Using PET imaging with a radiotracer specific for the serotonin transporter (5-HTT),

Indexed as

Positron-Emission TomographyAdultAmygdalaAniline CompoundsFemaleHumansImage Interpretation, Computer-AssistedMajor Depressive DisorderMalePrognosisProspective StudiesReceptor, Serotonin, 5-HT1ASerotonin Plasma Membrane Transport ProteinsSulfides3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrileAniline CompoundsReceptor, Serotonin, 5-HT1ASerotonin Plasma Membrane Transport ProteinsSulfidesdepressionmolecular imagingotherPETPET imagingpredictionremissionserotonin transporter

Identifiers

PMID28935838
PMCPMC5932749
OpenAlexW2758834692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.