ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018
Total-Body PET: Maximizing Sensitivity to Create New Opportunities for Clinical Research and Patient Care.
Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04941248 (The Application of Total-body 13N-NH3 PET/CT to Study the Blood Perfusion System in Severe AS Patients Before and After TAVR Surgery in the Whole Body), which is not on this map. Cited by 356 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Application of Total-body 13N-NH3 PET/CT to Study the Blood Perfusion System in Severe AS Patients Before and After TAVR Surgery in the Whole Body
Who cites it
356 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Applicability and performance ofJapanese journal of radiology · 2025Pooled it
- The historical progression of positron emission tomography research in neuroendocrinology.Frontiers in neuroendocrinology · 2023Pooled it
- PET Imaging of Sphingolipid Signaling: Current Radiotracers, Translational Gaps, and Opportunities in Neurodegeneration and Oncology.ACS omega · 2026Review
- First-in-human dosimetry and biodistribution of [European journal of nuclear medicine and molecular imaging · 2026Article
- Mechanistic insights for the preparation of improved metal-fluoride based radioimaging agents.Chemical science · 2026Article
- From sensitivity gain to clinical decisions: total-body and long-axial-field-of-view PET/CT for diagnosis and image-based management in oncology and systemic disease.Annals of nuclear medicine · 2026Review
- Delayed total-body [European journal of nuclear medicine and molecular imaging · 2026Article
- Functional Renal Assessment via Dynamic LAFOVJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Are liver metastases from uveal melanoma a clinical indication for dynamic PET? A comparison of Patlak parametric imaging with standard and delayed static SUV imaging using long axial field-of-view PET/CT.European journal of nuclear medicine and molecular imaging · 2026Article
- Realization of long axial field-of-view PET technology in the clinic and research environment.The British journal of radiology · 2026Review
- Cardiovascular imaging with total-body PET.The British journal of radiology · 2026Review
- Detailed pharmacokinetic features of a novel bis-boronEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Systems medicine: total body positron emission tomography meets omics.The British journal of radiology · 2026Review
- Patlak-Guided Self-Supervised Learning for Dynamic PET Denoising.IEEE transactions on radiation and plasma medical sciences · 2026Article
- Human cerebral cortex organization characterized by functional PET-FDG "Metabolic Connectivity".European journal of nuclear medicine and molecular imaging · 2026Article
- Performance of detector modules designed for the NeuroSphere brain PET system.Medical physics · 2026Article
- Large axial field of view PET/CT - Not just a longer PET gantry.Zeitschrift fur medizinische Physik · 2026Review
- Quantification of image quality and partial volume effect along the axial field-of-view of uMI Panorama GS PET/CT system for multiple radionuclides.EJNMMI physics · 2026Article
- Whole-Body Dynamic Positron Emission and Computed Tomography (WBD-PET/CT): Latest Developments, Challenges and Opportunities.Diagnostics (Basel, Switzerland) · 2026Review
- A rapid total-body PET imaging approach for pediatric patients using non-attenuation-corrected PET scans.EJNMMI physics · 2026Article
296 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
PET is widely considered the most sensitive technique available for noninvasively studying physiology, metabolism, and molecular pathways in the living human being. However, the utility of PET, being a photon-deficient modality, remains constrained by factors including low signal-to-noise ratio, long imaging times, and concerns about radiation dose. Two developments offer the potential to dramatically increase the effective sensitivity of PET. First by increasing the geometric coverage to encompass the entire body, sensitivity can be increased by a factor of about 40 for total-body imaging or a factor of about 4-5 for imaging a single organ such as the brain or heart. The world's first total-body PET/CT scanner is currently under construction to demonstrate how this step change in sensitivity affects the way PET is used both in clinical research and in patient care. Second, there is the future prospect of significant improvements in timing resolution that could lead to further effective sensitivity gains. When combined with total-body PET, this could produce overall sensitivity gains of more than 2 orders of magnitude compared with existing state-of-the-art systems. In this article, we discuss the benefits of increasing body coverage, describe our efforts to develop a first-generation total-body PET/CT scanner, discuss selected application areas for total-body PET, and project the impact of further improvements in time-of-flight PET.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.