Evidence map›Paper›PMID 28935763›Full record

ArticleBioscience reports2017

Long noncoding RNA ILF3-AS1 promotes cell proliferation, migration, and invasion via negatively regulating miR-200b/a/429 in melanoma.

Xiangjun Chen, Sha Liu, Xiaochun Zhao, Xiao Ma, Guozhen Gao, Li Yu, Dexiong Yan, Hao Dong, Weijing Sun

Open access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 57 citations in OpenAlex.

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  16. miRNAs in the Diagnosis and Prognosis of Skin Cancer.Frontiers in cell and developmental biology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xiangjun ChenDepartment of Burn and Plastic Surgery, The 253rd Hospital of PLA, Hohhot, Inner Mongolia 010051, China cxj_253@163.com.
Sha LiuDepartment of Burn and Plastic Surgery, The 253rd Hospital of PLA, Hohhot, Inner Mongolia 010051, China.
Xiaochun ZhaoDepartment of Burn and Plastic Surgery, The 253rd Hospital of PLA, Hohhot, Inner Mongolia 010051, China.
Xiao MaDepartment of Burn and Plastic Surgery, The 253rd Hospital of PLA, Hohhot, Inner Mongolia 010051, China.
Guozhen GaoDepartment of Burn and Plastic Surgery, The 253rd Hospital of PLA, Hohhot, Inner Mongolia 010051, China.
Li YuIntensive Care Unit, The 253rd Hospital of PLA, Hohhot, Inner Mongolia 010051, China.
Dexiong YanDepartment of Burn and Plastic Surgery, The 253rd Hospital of PLA, Hohhot, Inner Mongolia 010051, China.
Hao DongDepartment of General Surgery, The 253rd Hospital of PLA, Hohhot, Inner Mongolia 010051, China.
Weijing SunDepartment of Burn and Plastic Surgery, The 253rd Hospital of PLA, Hohhot, Inner Mongolia 010051, China.
Fourth Hospital of Inner Mongolia · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoma is the most malignant skin cancer, which account for most of skin-cancer-related deaths. Long noncoding RNA (lncRNA) is a class of noncoding RNAs with crucial roles in many cancers. However, the roles of lncRNAs in melanoma have not been well studied. In the present study, using public available data and clinical tissues samples, we found that lncRNA ILF3-AS1 is up-regulated in melanoma tissues and cell lines, and correlated with poor prognosis of melanoma patients. Functional experiments showed that knockdown of ILF3-AS1 inhibits melanoma cell proliferation, migration, and invasion. Mechanistically, we found that ILF3-AS1 interacts with EZH2, promotes the binding of EZH2 to the

Indexed as

Gene Expression Regulation, NeoplasticCell Line, TumorCell MovementCell ProliferationEnhancer of Zeste Homolog 2 ProteinHumansMelanocytesMelanomaMicroRNAsPrognosisPromoter Regions, GeneticRNA, Long NoncodingRNA, Small InterferingSignal TransductionSkin NeoplasmsSurvival AnalysisEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanMicroRNAsMIRN200 microRNA, humanRNA, Long NoncodingRNA, Small Interferingcell migrationEZH2long noncoding RNAmelanomamiR-200sproliferation

Identifiers

PMID28935763
PMCPMC5672086
OpenAlexW2760283151

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.