Evidence map›Paper›PMID 28935755›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2017

Leptin Induces Sca-1

Yao Xie, Claire M F Potter, Alexandra Le Bras, Witold N Nowak, Wenduo Gu, Shirin Issa Bhaloo, Zhongyi Zhang, Yanhua Hu, Li Zhang, Qingbo Xu

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. ATP purinergic receptor signalling promotes Sca-1Cell communication and signaling : CCS · 2023
    Article
  5. Review
  6. Vascular Stem/Progenitor Cells in Vessel Injury and Repair.Frontiers in cardiovascular medicine · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Leptin-induced signaling pathways in cancer cell migration and invasion.Cellular oncology (Dordrecht, Netherlands) · 2019
    Review
  13. Vascular progenitor cell senescence in patients with Marfan syndrome.Journal of cellular and molecular medicine · 2019
    Article
  14. Article
  15. Reporting Sex and Sex Differences in Preclinical Studies.Arteriosclerosis, thrombosis, and vascular biology · 2018
    Article
  16. Impact of miRNA in Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2018
    Review
  17. Emerging Roles for Adipose Tissue in Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2018
    Review
  18. Review
  19. Vascular Development.Arteriosclerosis, thrombosis, and vascular biology · 2018
    Review
  20. Mechanotransduction in Coronary Vein Graft Disease.Frontiers in cardiovascular medicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Yao XieFrom the Cardiovascular Division, King's College London BHF Centre, United Kingdom (Y.X., C.M.F.P., W.N.N., A.L.B., W.G., S.I.B., Z.Z., Y.H., Q.X.); and Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, China (L.Z.).
Claire M F PotterFrom the Cardiovascular Division, King's College London BHF Centre, United Kingdom (Y.X., C.M.F.P., W.N.N., A.L.B., W.G., S.I.B., Z.Z., Y.H., Q.X.); and Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, China (L.Z.).
Alexandra Le BrasFrom the Cardiovascular Division, King's College London BHF Centre, United Kingdom (Y.X., C.M.F.P., W.N.N., A.L.B., W.G., S.I.B., Z.Z., Y.H., Q.X.); and Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, China (L.Z.).
Witold N NowakFrom the Cardiovascular Division, King's College London BHF Centre, United Kingdom (Y.X., C.M.F.P., W.N.N., A.L.B., W.G., S.I.B., Z.Z., Y.H., Q.X.); and Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, China (L.Z.).
Wenduo GuFrom the Cardiovascular Division, King's College London BHF Centre, United Kingdom (Y.X., C.M.F.P., W.N.N., A.L.B., W.G., S.I.B., Z.Z., Y.H., Q.X.); and Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, China (L.Z.).
Shirin Issa BhalooFrom the Cardiovascular Division, King's College London BHF Centre, United Kingdom (Y.X., C.M.F.P., W.N.N., A.L.B., W.G., S.I.B., Z.Z., Y.H., Q.X.); and Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, China (L.Z.).
Zhongyi ZhangFrom the Cardiovascular Division, King's College London BHF Centre, United Kingdom (Y.X., C.M.F.P., W.N.N., A.L.B., W.G., S.I.B., Z.Z., Y.H., Q.X.); and Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, China (L.Z.).
Yanhua HuFrom the Cardiovascular Division, King's College London BHF Centre, United Kingdom (Y.X., C.M.F.P., W.N.N., A.L.B., W.G., S.I.B., Z.Z., Y.H., Q.X.); and Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, China (L.Z.).
Li ZhangFrom the Cardiovascular Division, King's College London BHF Centre, United Kingdom (Y.X., C.M.F.P., W.N.N., A.L.B., W.G., S.I.B., Z.Z., Y.H., Q.X.); and Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, China (L.Z.).
Qingbo XuFrom the Cardiovascular Division, King's College London BHF Centre, United Kingdom (Y.X., C.M.F.P., W.N.N., A.L.B., W.G., S.I.B., Z.Z., Y.H., Q.X.); and Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, China (L.Z.). qingbo.xu@kcl.ac.uk yanhua.hu@kcl.ac.uk.
Cardiovascular Research Center · BR

Funding

British Heart Foundation RG/14/6/31144
6 · The paper itself

Abstract

objectiveLeptin is an adipokine initially thought to be a metabolic factor. Recent publications have shown its roles in inflammation and vascular disease, to which Sca-1 APPROACH AND

resultsSca-1

conclusionsUpregulation of leptin levels in both the vessel wall and the circulation after vessel injury promoted the migration of Sca-1

Indexed as

Cell MovementNeointimaAnimalsAntigens, Lycdc42 GTP-Binding ProteinCells, CulturedDisease Models, AnimalExtracellular Signal-Regulated MAP KinasesFemoral ArteryFocal Adhesion Kinase 1Genetic Predisposition to DiseaseLeptinMaleMembrane ProteinsMice, KnockoutMuscle, Smooth, VascularAntigens, Lycdc42 GTP-Binding ProteinCdc42 protein, mouseExtracellular Signal-Regulated MAP KinasesFocal Adhesion Kinase 1Leptinleptin receptor, mouseLy6a protein, mouseMembrane ProteinsNeuropeptidesPtk2 protein, mouserac1 GTP-Binding ProteinRac1 protein, mouseReceptors, LeptinStat3 protein, mouseSTAT3 Transcription Factoradipokinesadventitialeptinmiceneointima

Identifiers

PMID28935755
PMCPMC5671780
OpenAlexW2758639811

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.