ArticleDevelopment (Cambridge, England)2017
Macrophages are required to coordinate mouse digit tip regeneration.
Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed.
- Single-cell foundation modeling with species-native protein tokens links regenerative competence across frog and mouse.bioRxiv : the preprint server for biology · 2026Article
- Review
- Single-Cell dissection of fibrodysplasia ossificans progressiva identifies SPP1 as a mediator of macrophage-fibroadipogenic progenitors crosstalk.Cellular and molecular life sciences : CMLS · 2026Article
- Macrophage metabolism directs regenerative versus fibrotic healing through BMP signaling in the mouse digit tip.bioRxiv : the preprint server for biology · 2026Article
- Digit regeneration in mice is stimulated by sequential treatment with FGF2 and BMP2.Nature communications · 2026Article
- Signal control during tissue regeneration in adult animals.Nature reviews. Molecular cell biology · 2026Review
- Breaking down to rebuild: lymphatic ablation enhances osteoclast-driven regeneration.The Journal of clinical investigation · 2026Article
- Targeting lymphatic vessels enhances bone regeneration by augmenting osteoclast activity in mouse models of amputation.The Journal of clinical investigation · 2026Article
- Macrophages orchestrate tail regeneration in lizardsFrontiers in cell and developmental biology · 2026Article
- Shared M0 macrophage infiltration-related gene signatures in osteoarthritis and osteomyelitis by integrating bulk and single-cell RNA transcriptome.European journal of medical research · 2025Article
- Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Macrophages generated in 3D mechanical microenvironment contribute to recruiting Peritonitis-associated neutrophils in vivo.Stem cell research & therapy · 2025Article
- Transcriptomic landscape around wound bed defines regenerative versus non-regenerative outcomes in mouse digit amputation.PLoS computational biology · 2025Article
- Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets.Signal transduction and targeted therapy · 2025Review
- Simulation of adult limb regeneration with lizard tail spinal cord implants reveals distinct roles of radial glia and microglia populations.Research square · 2025Article
- Article
- Osteoprogenitor cells from non-regenerative bone show greater resistance to cellular stress than those from regenerative bone.Frontiers in cell and developmental biology · 2025Article
- Tail Tales: What We Have Learned About Regeneration from Xenopus Laevis Tadpoles.International journal of molecular sciences · 2024Review
- Moderate beta-cell ablation triggers synergic compensatory mechanisms even in the absence of overt metabolic disruption.Communications biology · 2024Article
- Direct Current Electrical Stimulation Shifts THP-1-Derived Macrophage Polarization towards Pro-Regenerative M2 Phenotype.International journal of molecular sciences · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
In mammals, macrophages are known to play a major role in tissue regeneration. They contribute to inflammation, histolysis, re-epithelialization, revascularization and cell proliferation. Macrophages have been shown to be essential for regeneration in salamanders and fish, but their role has not been elucidated in mammalian epimorphic regeneration. Here, using the regenerating mouse digit tip as a mammalian model, we demonstrate that macrophages are essential for the regeneration process. Using cell-depletion strategies, we show that regeneration is completely inhibited; bone histolysis does not occur, wound re-epithelialization is inhibited and the blastema does not form. Although rescue of epidermal wound closure in the absence of macrophages promotes blastema accumulation, it does not rescue cell differentiation, indicating that macrophages play a key role in the redifferentiation of the blastema. We provide additional evidence that although bone degradation is a component, it is not essential to the overall regenerative process. These findings show that macrophages play an essential role in coordinating the epimorphic regenerative response in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.