Evidence map›Paper›PMID 28935705›Full record

ArticleDevelopment (Cambridge, England)2017

A tectorin-based matrix and planar cell polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane.

Richard J Goodyear, Xiaowei Lu, Michael R Deans, Guy P Richardson

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Kölliker's Organ Functions as a Developmental Hub in Mouse Cochlea Regulating Spiral Limbus and Tectorial Membrane Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Development of the cochlea.Development (Cambridge, England) · 2020
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. The Tectorial Membrane: Mechanical Properties and Functions.Cold Spring Harbor perspectives in medicine · 2019
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Richard J GoodyearSussex Neuroscience, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK r.j.goodyear@sussex.ac.uk.ORCID 0000-0001-6698-4127
Xiaowei LuDepartment of Cell Biology, University of Virginia Health System, Charlottesville, VA 22098, USA.
Michael R DeansDepartment of Surgery, Division of Otolaryngology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.ORCID 0000-0001-6319-7945
Guy P RichardsonSussex Neuroscience, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.ORCID 0000-0001-8476-0223
University of Sussex · GBUniversity of Utah · USUniversity of Virginia Health System · US

Funding

University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI PAUL STEVEN BERNSTEIN · 2005 to 2026
$14.6M
Planar Polarity Mechanisms in Mammalian Inner Ear DevelopmentR01DC013066 · NIDCD · UNIVERSITY OF UTAH · PI MICHAEL R DEANS · 2013 to 2026
$4.7M
Microtubule-Mediated Mechanisms Underlying Hair Cell Development and DeafnessR01DC013773 · NIDCD · UNIVERSITY OF VIRGINIA · PI Xiaowei Lu · 2014 to 2026
$4.5M
Vision Research Training Grant at the University of UtahT32EY024234 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI DAVID KRIZAJ, Monica L Vetter · 2014 to 2026
$2.3M
NEI NIH HHS P30 EY014800NEI NIH HHS T32 EY024234NIDCD NIH HHS R01 DC013066NIDCD NIH HHS R01 DC013773Wellcome Trust 087377
6 · The paper itself

Abstract

The tectorial membrane is an extracellular structure of the cochlea. It develops on the surface of the auditory epithelium and contains collagen fibrils embedded in a tectorin-based matrix. The collagen fibrils are oriented radially with an apically directed slant - a feature considered crucial for hearing. To determine how this pattern is generated, collagen-fibril formation was examined in mice lacking a tectorin-based matrix, epithelial cilia or the planar cell polarity genes

Indexed as

AnimalsCell PolarityCiliaEpitheliumExtracellular MatrixExtracellular Matrix ProteinsFibrillar CollagensGPI-Linked ProteinsLIM Domain ProteinsMembrane ProteinsMice, KnockoutModels, BiologicalOrgan of CortiTectorial Membranebeta-tectorin, mouseExtracellular Matrix ProteinsFibrillar CollagensGPI-Linked ProteinsLIM Domain ProteinsMembrane ProteinsPrickle2 protein, mouseTecta protein, mouseCochleaCollagenHearingInner earPlanar cell polarityTectorial membrane

Identifiers

PMID28935705
PMCPMC5702074
OpenAlexW2757911575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.