ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2017
Diurnal Cortisol Interacts With Stressful Events to Prospectively Predict Depressive Symptoms in Adolescent Girls.
Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- The impact of parent-child relationship on adolescent social adjustment following childhood abuse: the moderation of the serotonergic multilocus genetic variation.Frontiers in psychiatry · 2026Article
- Unraveling the Complex Interplay Between Neuroinflammation and Depression: A Comprehensive Review.International journal of molecular sciences · 2025Review
- Measuring salivary cortisol in biobehavioral research: A systematic review and methodological considerations.Brain, behavior, & immunity - health · 2025Review
- Pre-pandemic socio-emotional vulnerability, internalizing and externalizing symptoms predict changes in hair cortisol concentrations in reaction to the COVID-19 pandemic in children.Psychoneuroendocrinology · 2022Article
- Hair cortisol as a risk marker for increased depressive symptoms among older adults during the COVID-19 pandemic.Psychoneuroendocrinology · 2022Article
- The Mediating and Moderating Roles of Life Skills and Cortisol in the Relationship Between Sleep Quality and Depressive Symptoms Among Chinese Adolescents With Childhood Household Dysfunction.Frontiers in psychiatry · 2022Article
- Theory of mind and hair cortisol in healthy young adults: the moderating effects of childhood trauma.European journal of psychotraumatology · 2022Article
- Differential Susceptibility to the Impact of the COVID-19 Pandemic on Working Memory, Empathy, and Perceived Stress: The Role of Cortisol and Resilience.Brain sciences · 2021Article
- Sleep problems in adolescence are prospectively linked to later depressive symptoms via the cortisol awakening response.Development and psychopathology · 2020Article
- Effects Of Early Trauma and Recent Stressors on Depression, Anxiety, and Anger.Frontiers in psychiatry · 2020Article
- Feasibility of a Complex Setting for Assessing Sleep and Circadian Rhythmicity in a Fragile X Cohort.Frontiers in psychiatry · 2020Article
- The cortisol awakening response (CAR) interacts with acute interpersonal stress to prospectively predict depressive symptoms among early adolescent girls.Psychoneuroendocrinology · 2019Article
- Cortisol awakening response and additive serotonergic genetic risk interactively predict depression in two samples: The 2019 Donald F. Klein Early Career Investigator Award Paper.Depression and anxiety · 2019Article
- Parental depression moderates the relationships of cortisol and testosterone with children's symptoms.Journal of affective disorders · 2019Article
- Interpersonal Stress Severity Longitudinally Predicts Adolescent Girls' Depressive Symptoms: the Moderating Role of Subjective and HPA Axis Stress Responses.Journal of abnormal child psychology · 2019Article
- Cultural neurobiology and the family: Evidence from the daily lives of Latino adolescents.Development and psychopathology · 2018Article
- The relationship between childhood adversity, recent stressors, and depression in college students attending a South African university.BMC psychiatry · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe aim of present study was to test the diathesis-stress model of depression using baseline cortisol, prospective assessment of depression symptoms, and stressful life events.
methodsThe sample consisted of 527 adolescent girls aged 13.5-15.5 years without major depressive disorder. At baseline, saliva samples were collected at waking, 30 minutes after waking, and 8 p.m. on 3 consecutive days. Diurnal cortisol was indexed by cortisol awakening response (CAR) and area under the curve with respect to ground (AUCg). Stressful events during the preceding interval and current depressive symptoms were assessed 18 months following baseline.
resultsStressful events and the interaction of CAR or AUCg with stressful events predicted depressive symptoms at 18 months, even after controlling for baseline depressive symptoms. Specifically, in the face of high levels of stress, baseline blunted CAR or smaller AUCg were associated with future depressive symptoms. This was more apparent for CAR than AUCg. The effect was reversed at low levels of stress, with heightened CAR associated with more severe depressive symptoms.
conclusionsBlunted CAR and less daily cortisol output at baseline appear to accentuate the depressogenic effects of stressful events after 18 months, consistent with the diathesis-stress model of hypothalamic-pituitary-adrenal axis function in depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.