ReviewSeminars in immunology2017
Tailoring Natural Killer cell immunotherapy to the tumour microenvironment.
Review in Seminars in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Polysaccharides: Natural candidates for targeting immunometabolic regulation in hepatocellular carcinoma (Review).Molecular medicine reports · 2026Review
- Experimental study on synergistic pulses improving the tumor microenvironment and assisting immunotherapy.Frontiers in immunology · 2026Article
- Research Progress of NK Cells in Glioblastoma Treatment.OncoTargets and therapy · 2025Review
- Cholesterol-regulated cellular stiffness may enhance evasion of NK cell-mediated cytotoxicity in gastric cancer stem cells.FEBS open bio · 2024Article
- Advances in tumor microenvironment and underlying molecular mechanisms of bladder cancer: a systematic review.Discover oncology · 2024Review
- Transcriptional signature of CD56Frontiers in immunology · 2024Article
- Immune modulations of the tumor microenvironment in response to phototherapy.Journal of innovative optical health sciences · 2023Article
- LINC00963 May Be Associated with a Poor Prognosis in Patients with Cervical Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Review
- Improving PARP inhibitor efficacy in high-grade serous ovarian carcinoma: A focus on the immune system.Frontiers in genetics · 2022Review
- Natural killer cells in pancreatic cancer stroma.World journal of gastroenterology · 2021Review
- Phosphodiesterase 4A confers resistance to PGE2-mediated suppression in CD25EMBO reports · 2021Article
- Could Harnessing Natural Killer Cell Activity Be a Promising Therapy for Prostate Cancer?Critical reviews in immunology · 2021Review
- A Transcriptional Signature of IL-2 Expanded Natural Killer Cells Predicts More Favorable Prognosis in Bladder Cancer.Frontiers in immunology · 2021Article
- Review
- High GJB2 mRNA expression and its prognostic significance in lung adenocarcinoma: a study based on the TCGA database.Medicine · 2020Observational
- Single-cell transcriptome atlas of lung adenocarcinoma featured with ground glass nodules.Cell discovery · 2020Article
- The Role of NK Cells and Innate Lymphoid Cells in Brain Cancer.Frontiers in immunology · 2020Review
- PARP inhibition and immune modulation: scientific rationale and perspectives for the treatment of gynecologic cancers.Therapeutic advances in medical oncology · 2020Review
- Hepatic Tumor Microenvironments and Effects on NK Cell Phenotype and Function.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent anti-tumour activity. Accumulating evidence indicates that NK cell functions are severely compromised within the confines of the tumour microenvironment thus impairing the efficacy and development of NK cell-based therapies. Here we review the various cellular and molecular pathways that tumours have supplanted to evade NK cell surveillance. We highlight novel strategies designed to alleviate or circumvent the immunosuppressive conditions of the tumour microenvironment in order to emancipate NK cell function and stifle the inexorable growth and metastasis of malignant cells.
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Registered trials
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