ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2017
Testing the effects of adolescent alcohol use on adult conflict-related theta dynamics.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- An electroencephalographic signature predicts craving for methamphetamine.Cell reports. Medicine · 2024Article
- The Effects of Alcohol and Cannabis Use on the Cortical Thickness of Cognitive Control and Salience Brain Networks in Emerging Adulthood: A Co-twin Control Study.Biological psychiatry · 2021Article
- Parietal P3 and midfrontal theta prospectively predict the development of adolescent alcohol use.Psychological medicine · 2021Article
- Target-related parietal P3 and medial frontal theta index the genetic risk for problematic substance use.Psychophysiology · 2019Article
- Risk Behaviors in Teens with Chronic Kidney Disease: A Study from the Midwest Pediatric Nephrology Consortium.International journal of nephrology · 2019Article
- Conflict-related medial frontal theta as an endophenotype for alcohol use disorder.Biological psychology · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveAdolescent alcohol use (AAU) is associated with brain anomalies, but less is known about long-term neurocognitive effects. Despite theoretical models linking AAU to diminished cognitive control, empirical work testing this relationship with specific cognitive control neural correlates (e.g., prefrontal theta-band EEG dynamics) remains scarce. A longitudinal twin design was used to test the hypothesis that greater AAU is associated with reduced conflict-related EEG theta-band dynamics in adulthood, and to examine the genetic/environmental etiology of this association.
methodsIn a large (N=718) population-based prospective twin sample, AAU was assessed at ages 11/14/17. Twins completed a flanker task at age 29 to elicit EEG theta-band medial frontal cortex (MFC) power and medial-dorsal prefrontal cortex (MFC-dPFC) connectivity. Two complementary analytic methods (cotwin control analysis; biometric modeling) were used to disentangle the genetic/shared environmental risk towards AAU from possible alcohol exposure effects on theta dynamics.
resultsAAU was negatively associated with adult cognitive control-related theta-band MFC power and MFC-dPFC functional connectivity. Genetic influences primarily underlie these associations.
conclusionsFindings provide strong evidence that genetic factors underlie the comorbidity between AAU and diminished cognitive control-related theta dynamics in adulthood. SIGNIFICANCE: Conflict-related theta-band dynamics appear to be candidate brain-based endophenotypes/mechanisms for AAU.
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