ArticleUltrasound in medicine & biology2017
Non-invasive, Rapid Ablation of Tissue Volume Using Histotripsy.
Article in Ultrasound in medicine & biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2021Pooled it
- Investigation of High Pulse Repetition Frequency Single-Cycle Histotripsy for Rapid Tissue Ablation.Ultrasound in medicine & biology · 2026Article
- Surgery Without Scalpel: Histotripsy as a Non-Invasive and Non-Thermal Modality for Liver Tumor Ablation.Journal of clinical medicine · 2025Review
- Interventional Oncology for Colorectal Liver Metastases: From Local Cure to Salvage Therapy.Biomedicines · 2025Review
- Development of Histotripsy as a Local-Regional Liver Cancer Therapy: Preclinical to Clinical Translation.Radiology. Imaging cancer · 2025Review
- In Vivo Cavitation-Based Aberration Correction of Histotripsy in Porcine Liver.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Histotripsy: A Method for Mechanical Tissue Ablation with Ultrasound.Annual review of biomedical engineering · 2024Review
- Update on Percutaneous Ablation for Sarcoma.Current oncology reports · 2024Review
- Fundamentals and Applications of Focused Ultrasound-Assisted Cancer Immune Checkpoint Inhibition for Solid Tumors.Pharmaceutics · 2024Review
- Insights fromInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024Review
- Non-Thermal Liver Ablation: Existing and New Technology.Seminars in interventional radiology · 2023Review
- Research progress and clinical evaluation of histotripsy: a narrative review.Annals of translational medicine · 2023Review
- Mechanical High-Intensity Focused Ultrasound (Histotripsy) in Dogs With Spontaneously Occurring Soft Tissue Sarcomas.IEEE transactions on bio-medical engineering · 2023Article
- Characterizing the Ablative Effects of Histotripsy for Osteosarcoma: In Vivo Study in Dogs.Cancers · 2023Article
- Ultrasound-guided noninvasive pancreas ablation using histotripsy: feasibility study in anInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023Article
- A review of the development of histotripsy for extremity tumor ablation with a canine comparative oncology model to inform human treatments.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023Review
- Development of an ultrasound guided focused ultrasound system for 3D volumetric low energy nanodroplet-mediated histotripsy.Scientific reports · 2022Article
- A Modular, Kerf-Minimizing Approach for Therapeutic Ultrasound Phased Array Construction.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- The role of anti-tumor immunity of focused ultrasound for the malignancies: depended on the different ablation categories.International journal of clinical oncology · 2022Review
- Interventional oncology: new techniques and new devices.The British journal of radiology · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Histotripsy is a non-invasive, non-thermal ablation technique that uses high-amplitude, focused ultrasound pulses to fractionate tissue via acoustic cavitation. The goal of this study was to illustrate the potential of histotripsy with electronic focal steering to achieve rapid ablation of a tissue volume at a rate matching or exceeding those of current clinical techniques (∼1-2 mL/min). Treatment parameters were established in tissue-mimicking phantoms and applied to ex vivo tissue. Six-microsecond pulses were delivered by a 250-kHz array. The focus was electrically steered to 1000 locations at a pulse repetition frequency of 200 Hz (0.12% duty cycle). Magnetic resonance imaging and histology of the treated tissue revealed a distinct region of necrosis in all samples. Mean lesion volume was 35.6 ± 4.3 mL, generated at 0.9-3.3 mL/min, a speed faster than that of any current ablation method for a large volume. These results suggest that histotripsy has the potential to achieve non-invasive, rapid, homogeneous ablation of a tissue volume.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.