Evidence map›Paper›PMID 28935101›Full record

ArticleMethods in enzymology2017

Chemoenzymatic Synthesis and Applications of Prokaryote-Specific UDP-Sugars.

Cristina Y Zamora, Nathaniel S Schocker, Michelle M Chang, Barbara Imperiali

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in enzymology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Metabolic Engineering ofFrontiers in bioengineering and biotechnology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Cristina Y ZamoraMassachusetts Institute of Technology, Cambridge, MA, United States.
Nathaniel S SchockerMassachusetts Institute of Technology, Cambridge, MA, United States.
Michelle M ChangMassachusetts Institute of Technology, Cambridge, MA, United States.
Barbara ImperialiMassachusetts Institute of Technology, Cambridge, MA, United States. Electronic address: imper@mit.edu.
Massachusetts Institute of Technology · US

Funding

Inhibition of Prokaryote-Specific Saccharide Biosynthesis in Microbial PathogensR01GM097241 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI IMPERIALI, BARBARA · 2012 to 2017
$1.8M
NIGMS NIH HHS R01 GM097241
6 · The paper itself

Abstract

This method describes the chemoenzymatic synthesis of several nucleotide sugars, which are essential substrates in the biosynthesis of prokaryotic N- and O-linked glycoproteins. Protein glycosylation is now known to be widespread in prokaryotes and proceeds via sequential action of several enzymes, utilizing both common and modified prokaryote-specific sugar nucleotides. The latter, which include UDP-hexoses such as UDP-diNAc-bacillosamine (UDP-diNAcBac), UDP-diNAcAlt, and UDP-2,3-diNAcManA, are also important components of other bacterial and archaeal glycoconjugates. The ready availability of these "high-value" intermediates will enable courses of study into inhibitor screening, glycoconjugate biosynthesis pathway discovery, and unnatural carbohydrate incorporation toward metabolic engineering.

Indexed as

ArchaeaBacteriaCarbohydratesGlycoconjugatesGlycoproteinsGlycosylationMetabolic EngineeringNucleotidesUridine Diphosphate SugarsCarbohydratesGlycoconjugatesGlycoproteinsNucleotidesUridine Diphosphate Sugars2,3-di-N-acetyl-glucuronic acid2,4-di-N-acetyl-bacillosamineChemoenzymatic synthesisGlycoconjugate biosynthesisNucleotide-activated carbohydratesPseudaminic acid

Identifiers

PMID28935101
PMCPMC6710627
OpenAlexW2733724482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.