Evidence map›Paper›PMID 28934762›Full record

Trial reportBritish journal of cancer2017

Dose-response effects of aerobic exercise on body composition among colon cancer survivors: a randomised controlled trial.

Justin C Brown, Babette S Zemel, Andrea B Troxel, Michael R Rickels, Nevena Damjanov, Bonnie Ky, Andrew D Rhim, Anil K Rustgi, Kerry S Courneya, Kathryn H Schmitz

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 5 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Pooled it
  6. Trial
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  9. Article
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  12. Review
  13. Obesity and Breast Cancer Risk: The Oncogenic Implications of Metabolic Dysregulation.The Journal of clinical endocrinology and metabolism · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Exercise as a prescription for patients with various diseases.Journal of sport and health science · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Justin C BrownDivision of Population Science & Gastrointestinal Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Babette S ZemelDivision of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Andrea B TroxelDepartment of Population Health, NYU School of Medicine, New York, NY 10016, USA.
Michael R RickelsDivsion of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania, PA 19104, USA.
Nevena DamjanovDivision of Medical Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bonnie KyDivision of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Andrew D RhimDepartment of Gastroenterology Hepatology & Nutrition, M.D. Anderson Cancer Center, Houston, TX 77230, USA.
Anil K RustgiDivision of Gastroenterology, Department of Medicine, University of Pennsylvania, PA 19104, USA.
Kerry S CourneyaDepartment of Physical Activity and Recreation, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Kathryn H SchmitzDepartment of Public Health Science, College of Medicine, Penn State College of Medicine, Hershey, PA 17033, USA.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USDana-Farber Cancer Institute · USNew York University · USPenn State Milton S. Hershey Medical Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of Alberta · CA

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3M
Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
The Women In Steady Exercise Research (WISER) SurwVor TrialU54CA155850 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CHODOSH, LEWIS A · 2011 to 2015
$9.1M
The COURAGE Trial: Colon Recurrence and Aerobic Exercise: A Feasibility StudyR21CA182767 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SCHMITZ, KATHRYN H. · 2014 to 2015
$377k
Effects of Exercise on Visceral Adiposity & Hyperinsulinemia in Colon Cancer SurvivorF31CA192560 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BROWN, JUSTIN C · 2015 to 2016
$69k
NCATS NIH HHS UL1 TR000003NCI NIH HHS F31 CA192560NCI NIH HHS R21 CA182767NCI NIH HHS U54 CA155850NIDDK NIH HHS P30 DK019525
6 · The paper itself

Abstract

backgroundPhysical activity is associated with a lower risk of disease recurrence among colon cancer survivors. Excess visceral adipose tissue is associated with a higher risk of disease recurrence among colon cancer survivors. The pathways through which physical activity may alter disease outcomes are unknown, but may be mediated by changes in visceral adipose tissue.

methodsThirty-nine stage I-III colon cancer survivors were randomised to one of three groups: usual-care control, 150 min wk

resultsExercise reduced visceral adipose tissue in dose-response fashion (P

conclusionsAerobic exercise reduces visceral adipose tissue in dose-response fashion among patients with stage I-III colon cancer. Visceral adipose tissue may be a mechanism through which exercise reduces the risk of disease recurrence among colon cancer survivors.

Indexed as

Body CompositionCancer SurvivorsExerciseAdultAgedColonic NeoplasmsFemaleHumansIntra-Abdominal FatMaleMiddle AgedNeoplasm Recurrence, Local

Identifiers

PMID28934762
PMCPMC5729439
OpenAlexW2757923756

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.