ArticleNeuroimmunomodulation2017
The Effect of Perceived Stress on Epstein-Barr Virus Antibody Titers in Appalachian Ohio Women.
Article in Neuroimmunomodulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Relationships Among Maternal Epstein-Barr Virus Antibodies, COVID-19, and Stress in Mothers up to 1-Year Postpartum.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- LGBTQ+ identity and its association with inflammation and cellular immune function.Brain, behavior, and immunity · 2025Article
- Treatment of Epstein-Barr Induced Hepatitis with High Dose Intravenous Vitamin C: A Case Report.Integrative medicine (Encinitas, Calif.) · 2023Article
- Stress-Induced Epstein-Barr Virus Reactivation.Biomolecules · 2021Review
- A systematic review of the impact of psychosocial factors on immunity: Implications for enhancing BCG response against tuberculosis.SSM - population health · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveThe Appalachian population suffers a disparate burden of chronic stress leading to high perceived stress. The study aim was to determine the association between perceived stress and Epstein-Barr virus (EBV) antibody titers, along with the impact of perceived social support, Appalachian self-identify, and health behaviors.
methodsSerum EBV VCA-IgG antibody titer levels from 169 female Appalachian residents (aged 18-26 years) were examined. Perceived stress, perceived social support, Appalachian self-identity, and health behaviors were assessed via self-administered questionnaires.
resultsThere were 169 of 185 women positive for EBV. Among these women, the median EBV antibody titer level was 404 U/mL (range 101-6,464), and the overall geometric mean was 563.2 (95% CI 486.6-651.9). For a 1-point increase in perceived stress, the EBV antibody titer increased by 1.92% (95% CI 0.04-3.76%). For every point increase in perceived social support, the EBV antibody titer decreased by 1.00% (95% CI 0.06-1.98%). Perceived stress was significantly associated with sleep quality, BMI, and current smoking status, but not with binge-drinking, drug use, or Appalachian self-identity. No mediating effects of sleep quality, BMI, binge-drinking, current drug use, or >4 sexual partners were observed in the relationship between perceived stress and EBV titer level.
conclusionYoung Appalachian women reported high levels of perceived stress that were significantly associated with higher EBV titers. Higher perceived social support was associated with lower EBV titers. Health behaviors and Appalachian self-identity did not impact the relationship between perceived stress and EBV titers.
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