SynthesisPloS one2017
The significant effects of cerebral microbleeds on cognitive dysfunction: An updated meta-analysis.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Baseline Cerebral Small Vessel Disease Predicting Long-Term Cognitive Decline in Transient Ischemic Attack Patients.European journal of neurology · 2026Observational
- Carotid intraplaque neovascularization and cerebral microbleeds: correlation assessed by plane-wave ultrasensitive flow imaging.Frontiers in neurology · 2026Article
- Factors associated with depression and cognitive impairment after cerebral hemorrhage surgery.Scientific reports · 2025Article
- Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of Alzheimer's disease-vulnerable regions.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Lower slow wave sleep and rapid eye-movement sleep are associated with brain atrophy of AD-vulnerable regions.bioRxiv : the preprint server for biology · 2025Article
- RevealingiScience · 2024Article
- Atrial fibrillation and dementia: not just a coincidence.Journal of geriatric cardiology : JGC · 2023Article
- Plasma Lipoprotein-Associated Phospholipase A2 Affects Cognitive Impairment in Patients with Cerebral Microbleeds.Neuropsychiatric disease and treatment · 2023Article
- Associations of Neurodegeneration Biomarkers in Cerebrospinal Fluid with Markers of Alzheimer's Disease and Vascular Pathology.Journal of Alzheimer's disease : JAD · 2023Article
- Influence of cerebral microbleeds on mechanical thrombectomy outcomes.Scientific reports · 2022Article
- Altered Brain Morphometry in Cerebral Small Vessel Disease With Cerebral Microbleeds: An Investigation Combining Univariate and Multivariate Pattern Analyses.Frontiers in neurology · 2022Article
- White matter changes, duration of hypertension, and age are associated with cerebral microbleeds in patients with different stages of hypertension.Quantitative imaging in medicine and surgery · 2022Article
- Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936.Translational psychiatry · 2021Article
- Alzheimer disease.Nature reviews. Disease primers · 2021Review
- Jidong cognitive impairment cohort study: objectives, design, and baseline screening.Neural regeneration research · 2020Article
- Global Burden of Small Vessel Disease-Related Brain Changes on MRI Predicts Cognitive and Functional Decline.Stroke · 2020Article
- Risk factors of radiotherapy-induced cerebral microbleeds and serial analysis of their size compared with white matter changes: A 7T MRI study in 113 adult patients with brain tumors.Journal of magnetic resonance imaging : JMRI · 2019Article
- Cerebral microbleeds are associated with cognitive decline early after ischemic stroke.Journal of neurology · 2019Article
- Diverse Inflammatory Response After Cerebral Microbleeds Includes Coordinated Microglial Migration and Proliferation.Stroke · 2018Article
- The Involvement of Iron in Traumatic Brain Injury and Neurodegenerative Disease.Frontiers in neuroscience · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAccumulated data suggests that cerebral microbleeds (CMBs) play an important role in the decline of cognitive function, but the results remain inconsistent. In the current study, we aimed to investigate the association between CMBs and cognitive function, as well as the various effects of CMBs on different domains of cognition.
methodsWe searched through the databases of PubMed, Embase, Cochrane Library, and ScienceDirect. After a consistency test, the publication bias was evaluated and a sensitivity analysis was performed with combined odds ratios (OR) and standardized mean difference (SMD) of CMBs.
resultsA meta-analysis of 25 studies with 9343 participants total was conducted. Patients with CMBs had higher incidence of cognitive impairment (OR:3.5410; 95% confidence interval [CI] [2.2979, 5.4567], p<0.05) and lower scores of cognitive functions (SMD: -0.2700 [-0.4267, -0.1133], p<0.05 in Mini-Mental State Examination [MMSE] group and -0.4869 [-0.8902, -0.0818], p<0.05 in Montreal Cognitive Assessment [MoCA] group). Our results also indicated that patients with CMBs had obvious decline in cognitive functions, for instance, orientation (SMD: -0.9565 [-1.7260, -0.1869], p<0.05), attention and calculation (SMD: -1.1518 [-1.9553, -0.3484], p<0.05) and delayed recall (SMD: -0.5527 [-1.1043, -0.0011], p = 0.05).
conclusionsOur data suggested that CMBs might be an important risk factor for cognitive dysfunction, especially in the domains of orientation, attention and calculation and delayed recall functions. Prospective cohort studies with further investigations will be needed in larger samples.
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