ArticlePloS one2017
Quantitative optical coherence tomography angiography of macular vascular structure and foveal avascular zone in glaucoma.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03590899 (Semi-manual Vessel Density Analysis on Optical Coherence Tomography Angiography Images of Healthy Adults), which is not on this map. Cited by 81 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Semi-manual Vessel Density Analysis on Optical Coherence Tomography Angiography Images of Healthy Adults
Who cites it
81 citing papers in PubMed, 131 citations in OpenAlex.
- Glaucomatous vertical vessel density asymmetry of the temporal raphe detected with optical coherence tomography angiography.Scientific reports · 2020Trial
- Improved method for optical coherence tomography angiography: from reconstruction to clinical indicator quantification.Journal of biomedical optics · 2026Article
- A comparative evaluation of parafoveal and perifoveal macular vessel density loss in glaucoma using 3 × 3 mm OCTA scans.Scientific reports · 2026Article
- Assessment of Retinal Microcirculation in Primary Open-Angle Glaucoma Using Adaptive Optics and OCT Angiography: Correlation with Structural and Functional Damage.Journal of clinical medicine · 2025Article
- OCTA changes of retinal microvessels and thickness in moyamoya disease.Scientific reports · 2025Article
- Control of blood pressure and blood glucose levels has important clinical significance to the retina.BMC ophthalmology · 2025Article
- Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study.Investigative ophthalmology & visual science · 2025Article
- Automated Foveal Avascular Zone Segmentation in Optical Coherence Tomography Angiography Across Multiple Eye Diseases Using Knowledge Distillation.Bioengineering (Basel, Switzerland) · 2025Article
- Evaluating the effect of 0.125% atropine on foveal microvasculature using optical coherence tomography angiography.Scientific reports · 2025Article
- High-density perimetry in the assessment of foveal avascular zone and macular structure in glaucoma.PloS one · 2025Article
- Automated Support Generation for Fixed Partial Dentures and Impact of Bone Loss, Bone Quality and Support Types: Parametric Cad and Finite Element Analysis.Dentistry journal · 2024Article
- Optical coherence tomography angiography analysis of the fellow eye in unilateral pseudoexfoliation syndrome.BMC ophthalmology · 2024Article
- Choroidal and retinal vascular changes in HLA-B27-associated anterior uveitis.Japanese journal of ophthalmology · 2024Article
- Association of foveal avascular zone change and glaucoma progression.The British journal of ophthalmology · 2024Article
- Morphological characteristics of the foveal avascular zone in pathological myopia and its relationship with macular structure and microcirculation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Unveiling Novel Structural Biomarkers for the Diagnosis of Glaucoma.Biomedicines · 2024Review
- Widefield swept-source optical coherence tomography angiography metrics associated with neovascular glaucoma in patients with proliferative diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Applications of optical coherence tomography angiography in glaucoma: current status and future directions.Frontiers in medicine · 2024Review
- Comparison of an AI-based mobile pupillometry system and NPi-200 for pupillary light reflex and correlation with glaucoma-related markers.Frontiers in neurology · 2024Article
- OCTA characteristics in non-arteritic central retinal artery occlusion and correlation with visual acuity.International journal of ophthalmology · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe study aimed to evaluate the quantitative characteristics of the macular vessel density (VD) and foveal avascular zone (FAZ) in glaucoma using optical coherence tomography angiography (OCT-A).
designCross-sectional, age- and sex-matched case-control study.
methodsFifty-two eyes of 52 patients with primary open angle glaucoma and 52 eyes from 52 healthy participants were recruited retrospectively. OCT-A was performed on a 3 x 3-mm macular region centered on the fovea. OCT-A scans were manually graded to define the FAZ. Parafoveal VD in superficial and deep retina were analyzed in the circular- and quadrant-segmented zone. The FAZ parameters included size, perimeter, and circularity index. The regression analysis among VD and FAZ-related parameters and ocular parameters was performed, and the diagnostic ability was calculated with refractive error adjusted.
resultsFor both groups, the mean age and the sex ratio was not different between groups. With refractive error adjusted, the average macular VD was lower in glaucoma than in the control group for superficial (P = 0.013), deep (P<0.001), and the whole retina (P = 0.002). There were increased FAZ perimeter and decreased FAZ circularity index in glaucoma when compared with controls (P<0.001). In the multivariate regression models, FAZ circularity index were significantly associated with decreased peripapillary RNFL thickness (P = 0.007) and macular GCIPL thickness (P = 0.009) measured by OCT. The refractive-error adjusted area under receiver operating characteristics was highest for FAZ circularity index (0.905; 95% CI, 0.844-0.966), followed by temporal deep retinal VD (0.870; 95% CI, 0.803-0.937) and FAZ perimeter (0.858; 95% CI, 0.784-0.932).
conclusionsDecreased macular VD, increased FAZ perimeter, and decreased FAZ circularity index were observed in eyes with glaucoma using OCT-A. With refractive error adjusted, these parameters showed considerable diagnostic value for glaucoma. FAZ circularity index may be a novel biomarker representing disruption of the parafoveal capillary network in glaucoma, as supported by its association with structural parameters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.