ArticlePloS one2017
Automated computer-assisted quantitative analysis of intact murine lungs at the alveolar scale.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Synchrotron radiation based analyzer-free dual-phase dark-field lung imaging approach for radiography and CT.Scientific reports · 2025Article
- Alveolar Microdynamics during Tidal Ventilation in Live Animals Imaged by SPring-8 Synchrotron.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- 3D imaging of SARS-CoV-2 infected hamster lungs by X-ray phase contrast tomography enables drug testing.Scientific reports · 2024Article
- Article
- Deep 3D reconstruction of synchrotron X-ray computed tomography for intact lungs.Scientific reports · 2023Article
- Lung tissue biomechanics imaged with synchrotron phase contrast microtomography in live rats.Scientific reports · 2022Article
- Micrometer-resolution X-ray tomographic full-volume reconstruction of an intact post-mortem juvenile rat lung.Histochemistry and cell biology · 2021Article
- Preclinical hyperpolarizedNMR in biomedicine · 2020Article
- Tenascin-C deficiency impairs alveolarization and microvascular maturation during postnatal lung development.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Quantification of image texture in X-ray phase-contrast-enhanced projection images of in vivo mouse lungs observed at varied inflation pressures.Physiological reports · 2019Article
- Imaging cell morphology and physiology using X-rays.Biochemical Society transactions · 2019Review
- Alveolar Micromechanics in Bleomycin-induced Lung Injury.American journal of respiratory cell and molecular biology · 2018Article
- The micromechanics of lung alveoli: structure and function of surfactant and tissue components.Histochemistry and cell biology · 2018Review
- How high resolution 3-dimensional imaging changes our understanding of postnatal lung development.Histochemistry and cell biology · 2018Review
- Tomographic in vivo microscopy for the study of lung physiology at the alveolar level.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using state-of-the-art X-ray tomographic microscopy we can image lung tissue in three dimensions in intact animals down to a micrometer precision. The structural complexity and hierarchical branching scheme of the lung at this level of details, however, renders the extraction of biologically relevant quantities particularly challenging. We have developed a methodology for a detailed description of lung inflation patterns by measuring the size and the local curvature of the parenchymal airspaces. These quantitative tools for morphological and topological analyses were applied to high-resolution murine 3D lung image data, inflated at different pressure levels under immediate post mortem conditions. We show for the first time direct indications of heterogeneous intra-lobar and inter-lobar distension patterns at the alveolar level. Furthermore, we did not find any indication that a cyclic opening-and-collapse (recruitment) of a large number of alveoli takes place.
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