ArticleTranslational psychiatry2017
Metabolomics and cognition in African American adults in midlife: the atherosclerosis risk in communities study.
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Genetic loci of beta-aminoisobutyric acid are associated with aging-related mild cognitive impairment.Translational psychiatry · 2023Pooled it
- Metabolomics in the Development and Progression of Dementia: A Systematic Review.Frontiers in neuroscience · 2019Pooled it
- Urinary metabolomics data and cognitive performance in an adult population.Metabolic brain disease · 2026Article
- The blood metabolome of brain health in midlife and influences of genes, microbiome and exposome.Nature aging · 2026Article
- Metabolomic levels mediate the link between socioeconomic factors and changes in declarative memory in women with and without HIV.Brain, behavior, & immunity - health · 2026Article
- Metabolomic signatures of cognitive function in a type 2 Diabetes-Enriched cohort.Scientific reports · 2025Article
- The blood metabolome of cognitive function and brain health in middle-aged adults - influences of genes, gut microbiome, and exposome.medRxiv : the preprint server for health sciences · 2024Article
- Shared plasma metabolomic profiles of cognitive and mobility decline predict future dementia.GeroScience · 2024Article
- Metabolites and Cognitive Decline in a Puerto Rican Cohort.Journal of Alzheimer's disease : JAD · 2024Article
- Integrative metabolomics science in Alzheimer's disease: Relevance and future perspectives.Ageing research reviews · 2023Review
- Association of gut microbiota, plasma and fecal metabolite profiles with intellectual development in school-age children.Translational pediatrics · 2023Article
- Metabolic Syndrome as a Risk Factor for Alzheimer's Disease: A Focus on Insulin Resistance.International journal of molecular sciences · 2023Review
- Metabolites Associated with Memory and Gait: A Systematic Review.Metabolites · 2022Review
- Article
- Blood metabolites predicting mild cognitive impairment in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL).Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study.EBioMedicine · 2021Article
- Metabolites Associated with Early Cognitive Changes Implicated in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2021Article
- The Contribution of Kidney Disease to Cognitive Impairment in Patients with Type 2 Diabetes.Current diabetes reports · 2020Review
- Brain and blood metabolome for Alzheimer's dementia: findings from a targeted metabolomics analysis.Neurobiology of aging · 2020Article
- Metabolic Profiling of Cognitive Aging in Midlife.Frontiers in aging neuroscience · 2020Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
Clinical studies have shown alterations in metabolic profiles when patients with mild cognitive impairment and Alzheimer's disease dementia were compared to cognitively normal subjects. Associations between 204 serum metabolites measured at baseline (1987-1989) and cognitive change were investigated in 1035 middle-aged community-dwelling African American participants in the biracial Atherosclerosis Risk in Communities (ARIC) Study. Cognition was evaluated using the Delayed Word Recall Test (DWRT; verbal memory), the Digit Symbol Substitution Test (DSST; processing speed) and the Word Fluency Test (WFT; verbal fluency) at visits 2 (1990-1992) and 4 (1996-1998). In addition, Cox regression was used to analyze the metabolites as predictors of incident hospitalized dementia between baseline and 2011. There were 141 cases among 1534 participants over a median 17.1-year follow-up period. After adjustment for established risk factors, one standard deviation increase in N-acetyl-1-methylhistidine was significantly associated with greater 6-year change in DWRT scores (β=-0.66 words; P=3.65 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.