Evidence map›Paper›PMID 28934172›Full record

ReviewPharmaceutics2017

Topical Nano and Microemulsions for Skin Delivery.

Christofori M R R Nastiti, Thellie Ponto, Eman Abd, Jeffrey E Grice, Heather A E Benson, Michael S Roberts

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmaceutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed.

  1. Article
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  13. Life (Basel, Switzerland) · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Nanotechnology-driven nanoemulsion gel for enhanced transdermal delivery ofFrontiers in bioengineering and biotechnology · 2025
    Article
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christofori M R R NastitiSchool of Pharmacy, Curtin Health Innovation Research Institute, Curtin University, G.P.O. Box U1987, Perth, WA 6845, Australia. c.nastiti@postgrad.curtin.edu.au.
Thellie PontoSchool of Pharmacy, Curtin Health Innovation Research Institute, Curtin University, G.P.O. Box U1987, Perth, WA 6845, Australia. thellie.ponto@postgrad.curtin.edu.au.
Eman AbdTherapeutics Research Centre, The University of Queensland Diamentina Institute, Faculty of Medicine, Translational Research Institute, Woolloongabba, QLD 4102, Australia. e.abd@uq.edu.au.
Jeffrey E GriceTherapeutics Research Centre, The University of Queensland Diamentina Institute, Faculty of Medicine, Translational Research Institute, Woolloongabba, QLD 4102, Australia. jeff.grice@uq.edu.au.
Heather A E BensonSchool of Pharmacy, Curtin Health Innovation Research Institute, Curtin University, G.P.O. Box U1987, Perth, WA 6845, Australia. H.Benson@curtin.edu.au.
Michael S RobertsTherapeutics Research Centre, The University of Queensland Diamentina Institute, Faculty of Medicine, Translational Research Institute, Woolloongabba, QLD 4102, Australia. m.roberts@uq.edu.au.

Funding

Characterization of Critical Quality Attributes for Semisolid Topical Drug ProductsU01FD005226 · FDA · UNIVERSITY OF SOUTH AUSTRALIA · PI ROBERTS, MICHAEL · 2014 to 2018
$1.2M
Physiologically Based Biopharmaceutics and Pharmacokinetics of Drug Products for Dermal Absorption in HumansU01FD005232 · FDA · UNIVERSITY OF SOUTH AUSTRALIA · PI ROBERTS, MICHAEL · 2014 to 2016
$600k
FDA HHS U01 FD005226FDA HHS U01 FD005232
6 · The paper itself

Abstract

Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation. This review discusses nanosystems with utility in skin delivery and focuses on the composition and characterization of ME and NE for topical and transdermal delivery. The mechanism of skin delivery across the stratum corneum and via hair follicles is reviewed with particular focus on the influence of formulation.

Indexed as

microemulsionnanoemulsionnanosystempenetration enhancerskin penetrationtransdermal

Identifiers

PMID28934172
PMCPMC5750643

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.