Evidence map›Paper›PMID 28934151›Full record

ReviewViruses2017

Natural History of HPV Infection across the Lifespan: Role of Viral Latency.

Patti E Gravitt, Rachel L Winer

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05049252 (Performance of HPV E4 and p16INK4a Biomarkers in Predicting Risk of Regression Among Women Diagnosed With Cervical Intraepithelial Neoplasia Grade 2), which is not on this map. Cited by 140 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05049252 unknown statusnot on this mapstarted 2020, after this paper: background citation

Performance of HPV E4 and p16INK4a Biomarkers in Predicting Risk of Regression Among Women Diagnosed With Cervical Intraepithelial Neoplasia Grade 2 (CIN2): a Historical Cohort Study

TypeobservationalSponsorUniversity of AarhusRan2020 to 2023Enrolled500ConditionsCervical Intraepithelial Neoplasia Grade 2 (CIN2)
3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  10. Persistent, Asymptomatic Colonization withMicrobiology spectrum · 2022
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80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Patti E GravittDepartment of Global Health, George Washington University Milken Institute School of Public Health, Washington, DC 20052, USA. pgravitt@gwu.edu.
Rachel L WinerDepartment of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA. rlw@uw.edu.

Funding

HPV Infection Among Perimenopausal Women in the 1945-64 Birth CohorR01CA123467 · NCI · JOHNS HOPKINS UNIVERSITY · PI GRAVITT, PATTI E · 2007 to 2012
$3.1M
Natural History of HPV Infections in Mid-adult WomenP01AI083224 · NIAID · UNIVERSITY OF WASHINGTON · PI WINER, RACHEL L. · 2010 to 2010
$1.1M
NCI NIH HHS R01 CA123467NIAID NIH HHS P01 AI083224
6 · The paper itself

Abstract

Large-scale epidemiologic studies have been invaluable for elaboration of the causal relationship between persistent detection of genital human papillomavirus (HPV) infection and the development of invasive cervical cancer. However, these studies provide limited data to adequately inform models of the individual-level natural history of HPV infection over the course of a lifetime, and particularly ignore the biological distinction between HPV-negative tests and lack of infection (i.e., the possibility of latent, undetectable HPV infection). Using data from more recent epidemiological studies, this review proposes an alternative model of the natural history of genital HPV across the life span. We argue that a more complete elucidation of the age-specific probabilities of the alternative transitions is highly relevant with the expanded use of HPV testing in cervical cancer screening. With routine HPV testing in cervical cancer screening, women commonly transition in and out of HPV detectability, raising concerns for the patient and the provider regarding the source of the positive test result, its prognosis, and effective strategies to prevent future recurrence. Alternative study designs and analytic frameworks are proposed to better understand the frequency and determinants of these transition pathways.

Indexed as

LongevityVirus LatencyAdultAge FactorsFemaleHuman Papillomavirus DNA TestsHumansMiddle AgedPapillomaviridaePapillomavirus InfectionsPapillomavirus VaccinesPrognosisRecurrenceRisk FactorsUterine Cervical DysplasiaUterine Cervical NeoplasmsPapillomavirus Vaccinescervical cancerlatencypapillomavirus

Identifiers

PMID28934151
PMCPMC5691619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.