Evidence map›Paper›PMID 28934109›Full record

ArticleNutrients2017

Intestinal Production of Anti-Tissue Transglutaminase 2 Antibodies in Patients with Diagnosis Other Than Celiac Disease.

Mariantonia Maglio, Fabiana Ziberna, Rosita Aitoro, Valentina Discepolo, Giuliana Lania, Virginia Bassi, Erasmo Miele, Tarcisio Not, Riccardo Troncone, Renata Auricchio

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  5. [Intestinal and pharyngeal microbiota in early neonates: an analysis based on high-throughput sequencing].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Article
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  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
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  14. Article
  15. Review
  16. Article
  17. The serological diagnosis of coeliac disease - a step forward.Gastroenterology and hepatology from bed to bench · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mariantonia MaglioEuropean Laboratory for the Investigation of Food Induced Disease (ELFID), University Federico II, 80131 Naples, Italy. mariantonia.maglio@unina.it.
Fabiana ZibernaInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo" Trieste, 34137 Trieste, Italy. fabyz1@alice.it.
Rosita AitoroDepartment of Medical Translational Science, Section of Paediatrics, University Federico II, 80131 Naples, Italy. aitoro.rosita@gmail.com.
Valentina DiscepoloDepartment of Medical Translational Science, Section of Paediatrics, University Federico II, 80131 Naples, Italy. vale.discepolo@gmail.com.
Giuliana LaniaEuropean Laboratory for the Investigation of Food Induced Disease (ELFID), University Federico II, 80131 Naples, Italy. giuliana.lania@gmail.com.
Virginia BassiDepartment of Medical Translational Science, Section of Paediatrics, University Federico II, 80131 Naples, Italy. virginiabassi86@gmail.com.
Erasmo MieleDepartment of Medical Translational Science, Section of Paediatrics, University Federico II, 80131 Naples, Italy. erasmo.miele@unina.it.
Tarcisio NotInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo" Trieste, 34137 Trieste, Italy. tarcisio.not@burlo.trieste.it.
Riccardo TronconeEuropean Laboratory for the Investigation of Food Induced Disease (ELFID), University Federico II, 80131 Naples, Italy. troncone@unina.it.
Renata AuricchioEuropean Laboratory for the Investigation of Food Induced Disease (ELFID), University Federico II, 80131 Naples, Italy. r.auricchio@unina.it.
Federico II University Hospital · ITIRCCS Materno Infantile Burlo Garofolo · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been hypothesized that gluten-dependent production of anti-tissue-transglutaminase 2 (anti-TG2) antibodies may occur only at an intestinal level. We have investigated intestinal production of anti-TG2 antibodies in 136 patients with normal serum levels of anti-TG2 antibodies and normal duodenal mucosa. Intestinal deposits of anti-TG2 antibodies were evaluated by immunofluorescence and anti-TG2 antibodies released in organ culture supernatants measured by ELISA. Intestinal antibody libraries were obtained from 10 subjects. Immunohistochemistry for CD25⁺, CD3⁺, and TCR-γδ⁺ was assessed in subjects with positive (

Indexed as

AutoimmunityAutoantibodiesCeliac DiseaseChildDuodenumEnzyme-Linked Immunosorbent AssayFemaleFluorescent Antibody TechniqueGastrointestinal DiseasesGTP-Binding ProteinsHumansImmunity, MucosalIntestinal MucosaMaleOrgan Culture TechniquesProtein Glutamine gamma Glutamyltransferase 2AutoantibodiesGTP-Binding ProteinsProtein Glutamine gamma Glutamyltransferase 2Receptors, Antigen, T-Cell, gamma-deltaTGM2 protein, humanTransglutaminasesceliac diseaseintestinal anti-transglutaminase 2 antibodiespotential celiac diseaseTCR-γδ+ intraepithelial lymphocytes

Identifiers

PMID28934109
PMCPMC5691667
OpenAlexW2757478718

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.