ArticleCell cycle (Georgetown, Tex.)2017
Reconciling conflicting models for global control of cell-cycle transcription.
Article in Cell cycle (Georgetown, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Evolution of the Cell-Cycle Clock Models: Biochemical or Transcriptional?Advances in experimental medicine and biology · 2026Review
- The Emergent Architecture of Autonomous Clocks Described by Computational Algorithms of Regulatory Networks.Advances in experimental medicine and biology · 2026Article
- A yeast cell cycle pulse generator model shows consistency with multiple oscillatory and checkpoint mutant datasets.Mathematical biosciences · 2024Article
- Experimental guidance for discovering genetic networks through hypothesis reduction on time series.PLoS computational biology · 2022Article
- Review
- Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics.eLife · 2021Review
- Using extremal events to characterize noisy time series.Journal of mathematical biology · 2020Article
- Improved recovery of cell-cycle gene expression in Saccharomyces cerevisiae from regulatory interactions in multiple omics data.BMC genomics · 2020Article
- The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle.Cell cycle (Georgetown, Tex.) · 2019Article
- Quantitative Studies for Cell-Division Cycle Control.Frontiers in physiology · 2019Review
- Layers of regulation of cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae.Molecular biology of the cell · 2018Article
- Better together: Unifying discordant cell-cycle oscillator models.Cell cycle (Georgetown, Tex.) · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Models for the control of global cell-cycle transcription have advanced from a CDK-APC/C oscillator, a transcription factor (TF) network, to coupled CDK-APC/C and TF networks. Nonetheless, current models were challenged by a recent study that concluded that the cell-cycle transcriptional program is primarily controlled by a CDK-APC/C oscillator in budding yeast. Here we report an analysis of the transcriptome dynamics in cyclin mutant cells that were not queried in the previous study. We find that B-cyclin oscillation is not essential for control of phase-specific transcription. Using a mathematical model, we demonstrate that the function of network TFs can be retained in the face of significant reductions in transcript levels. Finally, we show that cells arrested at mitotic exit with non-oscillating levels of B-cyclins continue to cycle transcriptionally. Taken together, these findings support a critical role of a TF network and a requirement for CDK activities that need not be periodic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.