Evidence map›Paper›PMID 28934010›Full record

ArticleCancer biology & therapy2017

Down-regulation of KLF5 in cancer-associated fibroblasts inhibit gastric cancer cells progression by CCL5/CCR5 axis.

Tingsong Yang, Min Chen, Xiaohu Yang, Xiaobing Zhang, Zhou Zhang, Yingying Sun, Bin Xu, Jie Hua, Zhigang He, Zhenshun Song

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
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  15. Article
  16. Review
  17. Article
  18. Chemokine signaling in cancer-stroma communications.Journal of cell communication and signaling · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Tingsong Yanga Department of General Surgery , Shanghai Tenth Peoples' Hospital affiliated Tongji University , No. 301, Middle Yanchang Road, Shanghai , China.
Min Chenb Department of Pathology , Dahua Hospital, No. 901, Old Humin Road, Xuhui District, Shanghai , China.
Xiaohu Yangc Department of Anesthesiology , Shanghai East Hospital Affiliated Tongji University , No. 150, JiMo Road, Shanghai , China.
Xiaobing Zhanga Department of General Surgery , Shanghai Tenth Peoples' Hospital affiliated Tongji University , No. 301, Middle Yanchang Road, Shanghai , China.
Zhou Zhanga Department of General Surgery , Shanghai Tenth Peoples' Hospital affiliated Tongji University , No. 301, Middle Yanchang Road, Shanghai , China.
Yingying Suna Department of General Surgery , Shanghai Tenth Peoples' Hospital affiliated Tongji University , No. 301, Middle Yanchang Road, Shanghai , China.
Bin Xua Department of General Surgery , Shanghai Tenth Peoples' Hospital affiliated Tongji University , No. 301, Middle Yanchang Road, Shanghai , China.
Jie Huaa Department of General Surgery , Shanghai Tenth Peoples' Hospital affiliated Tongji University , No. 301, Middle Yanchang Road, Shanghai , China.
Zhigang Hea Department of General Surgery , Shanghai Tenth Peoples' Hospital affiliated Tongji University , No. 301, Middle Yanchang Road, Shanghai , China.
Zhenshun Songa Department of General Surgery , Shanghai Tenth Peoples' Hospital affiliated Tongji University , No. 301, Middle Yanchang Road, Shanghai , China.
Tongji University · CNShanghai Tenth People's Hospital · CNDahua Hospital · CNShanghai East Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It was well known that cancer-associated fibroblasts (CAFs) were an essential factor in tumor progression. However, the actual mechanism of stromal fibroblasts activation and tumor promoting effects remain unclear. Here, we showed that KLF5 expression was more frequently observed in gastric cancer-associated fibroblasts compared with normal mucosal fibroblasts. Moreover, KLF5 expression in tumor stroma was closely associated with clinicopathological features such as tumor size, invasion depth, cell grade and lymph node metastasis, as well as poor prognosis in patients with gastric cancer. In addition, we further demonstrated that KLF5-regulating CAFs affect gastric cancer cells progression by CCL5 secretion and activation of CCR5. Taken together, we concluded that KLF5 expression in gastric cancer-associated fibroblasts contribute to poor survival and promote cancer cells progression by activation of CCL5/CCR5 axis, which suggesting that KLF5 in CAFs might be considered as a promising target for the treatment of gastric cancer.

Indexed as

AnimalsCancer-Associated FibroblastsCell Line, TumorCell MovementChemokine CCL5Disease ProgressionDown-RegulationFemaleGastrectomyHumansKruppel-Like Transcription FactorsLymphatic MetastasisMaleMiceMice, Inbred BALB CMice, NudeCCL5 protein, humanCCR5 protein, humanChemokine CCL5KLF5 protein, humanKruppel-Like Transcription FactorsReceptors, CCR5Cancer-associated fibroblastsCCL5CCR5Gastric cancerKLF5

Identifiers

PMID28934010
PMCPMC5678703
OpenAlexW2757662540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.