Evidence map›Paper›PMID 28933920›Full record

ArticleAmerican journal of respiratory cell and molecular biology2018

Multitissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in Asthma.

Akul Singhania, Joshua C Wallington, Caroline G Smith, Daniel Horowitz, Karl J Staples, Peter H Howarth, Stephan D Gadola, Ratko Djukanović, Christopher H Woelk, Timothy S C Hinks

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Innate-like Gene Expression of Lung-Resident Memory CD8American journal of respiratory and critical care medicine · 2021
    Trial
  4. Article
  5. Article
  6. Distinct blood transcriptomic profiling underlying asthma establishment and exacerbation.The journal of allergy and clinical immunology. Global · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Unconventional Activation of IRE1 Enhances Th17 Responses and Promotes Airway Neutrophilia.American journal of respiratory cell and molecular biology · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. New targets for type 2-low asthma.The Korean journal of internal medicine · 2024
    Review
  18. Article
  19. Article
  20. The functional role of CST1 and CCL26 in asthma development.Immunity, inflammation and disease · 2024
    Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Akul Singhania1 Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, and.ORCID 0000-0002-6941-3618
Joshua C Wallington1 Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, and.
Caroline G Smith1 Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, and.
Daniel Horowitz3 Janssen Research and Development, High Wycombe, Buckinghamshire, United Kingdom.
Karl J Staples1 Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, and.ORCID 0000-0003-3844-6457
Peter H Howarth1 Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, and.
Stephan D Gadola1 Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, and.ORCID 0000-0002-5240-4643
Ratko Djukanović1 Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, and.ORCID 0000-0001-6039-5612
Christopher H Woelk1 Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, and.
Timothy S C Hinks1 Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, and.ORCID 0000-0003-0699-2373
University Hospital Southampton NHS Foundation Trust · GBJanssen (United Kingdom) · GBJohn Radcliffe Hospital · GBRoche (Switzerland) · CH

Funding

Medical Research Council G0800649Wellcome TrustWellcome Trust 088,365/Z/09/ZWellcome Trust 104,553/Z/14/Z
6 · The paper itself

Abstract

Asthma arises from the complex interplay of inflammatory pathways in diverse cell types and tissues. We sought to undertake a comprehensive transcriptomic assessment of the epithelium and airway T cells that remain understudied in asthma and investigate interactions between multiple cells and tissues. Epithelial brushings and flow-sorted CD3

Indexed as

AdultAgedAntigens, NeoplasmAsthmaCell Adhesion MoleculesChemokinesChloride ChannelsCystatinsEpithelial CellsFemaleGene Expression ProfilingHumansInterleukin-13Interleukin-17MaleMiddle AgedAntigens, NeoplasmCell Adhesion MoleculesChemokinesChloride ChannelsCLCA1 protein, humanCSF3R protein, humanCystatinsIL17A protein, humanInterleukin-13Interleukin-17POSTN protein, humanReceptors, Colony-Stimulating FactorSerpinssquamous cell carcinoma-related antigenasthmaBALepithelial brushingssputumtranscriptomics

Identifiers

PMID28933920
PMCPMC5805998
OpenAlexW2757730981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.