Evidence map›Paper›PMID 28933646›Full record

ArticleRNA biology2018

Visualizing tRNA-dependent mistranslation in human cells.

Jeremy T Lant, Matthew D Berg, Daniel H W Sze, Kyle S Hoffman, Ibukunoluwa C Akinpelu, Matthew A Turk, Ilka U Heinemann, Martin L Duennwald, Christopher J Brandl, Patrick O'Donoghue

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. RiboScreenBiomedicines · 2026
    Review
  3. Article
  4. Review
  5. Recent insights into HSP70: proteostasis and beyond.Frontiers in molecular biosciences · 2026
    Review
  6. Review
  7. Natural human tRNARNA (New York, N.Y.) · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Mistranslating tRNA variants have anticodon- and sex-specific impacts onbioRxiv : the preprint server for biology · 2024
    Article
  13. Engineered mischarged transfer RNAs for correcting pathogenic missense mutations.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  14. Missense suppressor tRNA therapeutics correct disease-causing alleles by misreading the genetic code.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  15. Article
  16. Electronic cigarette vapor disrupts key metabolic pathways in human lung epithelial cells.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  17. Article
  18. Perseverance of protein homeostasis despite mistranslation of glycine codons with alanine.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jeremy T Lanta Department of Biochemistry , The University of Western Ontario , London , ON , Canada.
Matthew D Berga Department of Biochemistry , The University of Western Ontario , London , ON , Canada.
Daniel H W Szea Department of Biochemistry , The University of Western Ontario , London , ON , Canada.
Kyle S Hoffmana Department of Biochemistry , The University of Western Ontario , London , ON , Canada.
Ibukunoluwa C Akinpelua Department of Biochemistry , The University of Western Ontario , London , ON , Canada.
Matthew A Turka Department of Biochemistry , The University of Western Ontario , London , ON , Canada.
Ilka U Heinemanna Department of Biochemistry , The University of Western Ontario , London , ON , Canada.
Martin L Duennwaldb Department of Pathology , The University of Western Ontario , London , ON , Canada.
Christopher J Brandla Department of Biochemistry , The University of Western Ontario , London , ON , Canada.
Patrick O'Donoghuea Department of Biochemistry , The University of Western Ontario , London , ON , Canada.
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-fidelity translation and a strictly accurate proteome were originally assumed as essential to life and cellular viability. Yet recent studies in bacteria and eukaryotic model organisms suggest that proteome-wide mistranslation can provide selective advantages and is tolerated in the cell at higher levels than previously thought (one error in 6.9 × 10

Indexed as

MutationProtein BiosynthesisRNA Processing, Post-TranscriptionalAlanineAminoacylationAmino Acyl-tRNA SynthetasesAnticodonCell SurvivalCodonCulture MediaEscherichia coliGenes, ReporterGlucoseGreen Fluorescent ProteinsHEK293 CellsHumansAlanineAmino Acyl-tRNA SynthetasesAnticodonCodonCulture Mediaenhanced green fluorescent proteinGlucoseGreen Fluorescent ProteinsProlineProteasome Endopeptidase ComplexRNA, Transfer, ProAminoacyl-tRNA synthetasecell stressgenetic codetranslationtRNA

Identifiers

PMID28933646
PMCPMC6103679
OpenAlexW2760281524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.