ArticleCell cycle (Georgetown, Tex.)2017
The pro-apoptotic BAX protein influences cell growth and differentiation from the nucleus in healthy interphasic cells.
Article in Cell cycle (Georgetown, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
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- Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak.Apoptosis : an international journal on programmed cell death · 2024Article
- Regulatory role of the miR-142-3p/Translational lung cancer research · 2024Article
- Acute Genetic Damage Induced by Ethanol and Corticosterone Seems to Modulate Hippocampal Astrocyte Signaling.International journal of cell biology · 2024Article
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- Nerve growth factor receptors in equine synovial membranes vary with osteoarthritic disease severity.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- BAX regulates dendritic spine development via mitochondrial fusion.Neuroscience research · 2022Article
- Diallyl trisulfide plays an antifibrotic role by inhibiting the expression of Bcl-2 in hepatic stellate cells.Journal of biochemical and molecular toxicology · 2022Article
- Proliferation and Apoptosis Pathways and Factors in Oral Squamous Cell Carcinoma.International journal of molecular sciences · 2022Review
- Regulatory Role of the RUNX2 Transcription Factor in Lung Cancer Apoptosis.International journal of cell biology · 2022Article
- Effects of propofol on cardiac function and miR-494 expression in rats with hepatic ischemia/reperfusion injury.The Journal of international medical research · 2021Article
- Essentiality of CTNNB1 in Malignant Transformation of Human Embryonic Stem Cells under Long-Term Suboptimal Conditions.Stem cells international · 2020Article
- PFN1 and integrin-β1/mTOR axis involvement in cornea differentiation of fibroblast limbal stem cells.Journal of cellular and molecular medicine · 2019Article
- Skin immunity and its dysregulation in psoriasis.Cell cycle (Georgetown, Tex.) · 2019Review
- Human Mesenchymal Stem Cell Secretome from Bone Marrow or Adipose-Derived Tissue Sources for Treatment of Hypoxia-Induced Pulmonary Epithelial Injury.International journal of molecular sciences · 2018Article
- Article
- When BAX doesn't kill.Cell cycle (Georgetown, Tex.) · 2018Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has become more and more evident that the BCL-2 family proteins mediate a wide range of non-apoptotic functions. The pro-apoptotic BAX protein has been reported in interphasic nuclei. Whether the nuclear form of BAX could be involved in non-apoptotic function is still unknown. Our study showed for the first time that BAX was associated with chromatin in vitro. Next, we used gain and loss of function approaches to decipher the potential role of nuclear BAX in non-apoptotic cells. In vitro, nuclear BAX promoted cell proliferation in lung epithelial cells and primary human lung fibroblasts by modulating CDKN1A expression. Interestingly, BAX occupancy of CDKN1A promoter was specifically enriched close to the transcription-starting site. Nuclear BAX also modulated the basal myofibroblastic differentiation and migration of primary human lung fibroblasts. Finally, BAX nuclear localization was associated in vivo with the remodelling of lung parenchyma during development, tumorigenesis as well as fibrosis compared to control adult human lungs. Hence, our study established for the first time, a strong link between the nuclear localization of the pro-apoptotic BAX protein and key basic cellular functions in the non-apoptotic setting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.