ArticleJournal of enzyme inhibition and medicinal chemistry2017
α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study.
Article in Journal of enzyme inhibition and medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
139 citing papers in PubMed, 3 syntheses or guidelines pooled it, 390 citations in OpenAlex.
- Flavonoids as Antidiabetic and Anti-Inflammatory Agents: A Review on Structural Activity Relationship-Based Studies and Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- Insights into the Pharmacological Effects of Flavonoids: The Systematic Review of Computer Modeling.International journal of molecular sciences · 2022Pooled it
- Cassava (Journal of evidence-based integrative medicinePooled it
- Comparative Enzyme Inhibitory and Antioxidant Activities of Selected Turkish Medicinal Plants With LC-MS/MS Profiling of Morus nigra Extract.Chemistry & biodiversity · 2026Article
- Evaluation of the Potential Hypoglycemic and Neuroprotective Effects of Rosehip Fruit.Molecules (Basel, Switzerland) · 2026Article
- Review
- A New Flavonoid Glycoside from the Stem Bark ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Effects of Household Cooking Methods on the Nutritional, Phytochemical and Functional Properties ofMolecules (Basel, Switzerland) · 2026Article
- Green Synthesized Gold Nanoparticles Using Naringin and Naringenin: Characterization, Biological Activities, and Cytogenotoxicity.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Bioactivity-Guided Identification of Metabolites fromMolecules (Basel, Switzerland) · 2026Article
- Deoxynojirimycin derivatives as potent α-glucosidase inhibitors: in silico ADMET evaluation, molecular dynamics and in vitro validation studies.Molecular diversity · 2026Article
- Inhibition of Diabetes-Related Enzymes by Plant Secondary Metabolites: A Promising Therapeutic Strategy.Life (Basel, Switzerland) · 2026Review
- Article
- Anti-Hyperglycemic and Antioxidant Effects ofInternational journal of molecular sciences · 2026Article
- Integrating Phytochemical Bioactivity and Glycemic Risk to Evaluate Fruits for Type 2 Diabetes Management: A Korean Market Perspective.Foods (Basel, Switzerland) · 2026Article
- Unveiling the Antidiabetic Potential ofMetabolites · 2026Article
- Article
- Interaction of diosmetin, diosmin and diosmetin-7-O-glucoside with human erythrocytes, their model membrane, hemoglobin and redox-active metal ions.Frontiers in molecular biosciences · 2026Article
- Targeting diabetes with flavonoids from Indonesian medicinal plants: a review on mechanisms and drug discovery.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Flavones fromRSC advances · 2025Article
79 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
α-Glucosidase inhibitors are described as the most effective in reducing post-prandial hyperglycaemia (PPHG) from all available anti-diabetic drugs used in the management of type 2 diabetes mellitus. As flavonoids are promising modulators of this enzyme's activity, a panel of 44 flavonoids, organised in five groups, was screened for their inhibitory activity of α-glucosidase, based on in vitro structure-activity relationship studies. Inhibitory kinetic analysis and molecular docking calculations were also applied for selected compounds. A flavonoid with two catechol groups in A- and B-rings, together with a 3-OH group at C-ring, was the most active, presenting an IC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.