ArticleCell transplantation2017
Implantation of Brain-Derived Extracellular Matrix Enhances Neurological Recovery after Traumatic Brain Injury.
Article in Cell transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue.Advanced healthcare materials · 2026Review
- In vitro evaluation of a decellularized human fetal skin-derived scaffold repopulated with human amniotic fluid stem cells for potential application in myelomeningocele repair.Scientific reports · 2026Article
- Point-of-Injury Treatment with Hydrogel Containing Dexamethasone Improves Cognitive Function and Reduces Secondary Injury Response After TBI.Gels (Basel, Switzerland) · 2025Article
- Design and Applications of Extracellular Matrix Scaffolds in Tissue Engineering and Regeneration.Cells · 2025Review
- Functional hydrogel for modulating lipid droplets and neuroinflammation in head injury.Advanced functional materials · 2025Article
- Region-specific brain decellularized extracellular matrix promotes cell recovery in an in vitro model of stroke.Scientific reports · 2025Article
- Injectable Brain Extracellular Matrix Hydrogels Enhance Neuronal Migration and Functional Recovery After Intracerebral Hemorrhage.Biomaterials research · 2025Article
- Suspension electrospinning of decellularized extracellular matrix: A new method to preserve bioactivity.Bioactive materials · 2024Article
- Overcoming big bottlenecks in vascular regeneration.Communications biology · 2024Review
- Loss of microRNA-15a/16-1 function promotes neuropathological and functional recovery in experimental traumatic brain injury.JCI insight · 2024Article
- Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application.Bioactive materials · 2024Review
- In vitro dose-dependent effects of matrix metalloproteinases on ECM hydrogel biodegradation.Acta biomaterialia · 2024Article
- Hydrogel in the Treatment of Traumatic Brain Injury.Biomaterials research · 2024Review
- Infusible Extracellular Matrix Biomaterial Promotes Vascular Integrity and Modulates the Inflammatory Response in Acute Traumatic Brain Injury.Advanced healthcare materials · 2023Article
- Functional acellular matrix for tissue repair.Materials today. Bio · 2023Review
- Porous Silicon Nanoparticles Targeted to the Extracellular Matrix for Therapeutic Protein Delivery in Traumatic Brain Injury.Bioconjugate chemistry · 2022Article
- Applications and Mechanisms of Stimuli-Responsive Hydrogels in Traumatic Brain Injury.Gels (Basel, Switzerland) · 2022Review
- Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering.Bioactive materials · 2022Review
- Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine.International journal of molecular sciences · 2022Review
- Decellularised extracellular matrix-based biomaterials for repair and regeneration of central nervous system.Expert reviews in molecular medicine · 2022Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Scaffolds composed of extracellular matrix (ECM) are being investigated for their ability to facilitate brain tissue remodeling and repair following injury. The present study tested the hypothesis that the implantation of brain-derived ECM would attenuate experimental traumatic brain injury (TBI) and explored potential underlying mechanisms. TBI was induced in mice by a controlled cortical impact (CCI). ECM was isolated from normal porcine brain tissue by decellularization methods, prepared as a hydrogel, and injected into the ipsilesional corpus callosum and striatum 1 h after CCI. Lesion volume and neurological function were evaluated up to 35 d after TBI. Immunohistochemistry was performed to assess post-TBI white matter integrity, reactive astrogliosis, and microglial activation. We found that ECM treatment reduced lesion volume and improved neurobehavioral function. ECM-treated mice showed less post-TBI neurodegeneration in the hippocampus and less white matter injury than control, vehicle-treated mice. Furthermore, ECM ameliorated TBI-induced gliosis and microglial pro-inflammatory responses, thereby providing a favorable microenvironment for tissue repair. Our study indicates that brain ECM hydrogel implantation improved the brain microenvironment that facilitates post-TBI tissue recovery. Brain ECM offers excellent biocompatibility and holds potential as a therapeutic agent for TBI, alone or in combination with other treatments.
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Registered trials
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