Evidence map›Paper›PMID 28933211›Full record

ReviewCell transplantation2017

Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors.

Michael Galgano, Gentian Toshkezi, Xuecheng Qiu, Thomas Russell, Lawrence Chin, Li-Ru Zhao

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 294 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
294citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04489082 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Use of Near Infrared Laser Stimulation for Treatment of Depression, Anxiety, Neurodegenerative Conditions, and Traumatic Brain Injury/Chronic Traumatic Encephalopathy

TypeinterventionalSponsorNeurological Associates of West Los AngelesRan2021 to 2024Enrolled400ConditionsRefractory Depression, Anxiety Disorders, Neurodegenerative Diseases, Traumatic Brain InjuryArmsNear Infrared Laser Stimulation
NCT06429774 recruitingnot on this mapstarted 2024, after this paper: background citation

Comparative Effectiveness of Intervention in Multi-level Hospitals for Acute Traumatic Brain Injury: a Prospective, Multicenter, Observational Cohort Study

Typeobservational_patient_registrySponsorBeijing Tiantan HospitalRan2024 to 2026Enrolled2,000ConditionsTraumatic Brain InjuryArmsNeurological function, Mental State, cognitive function, and life quality assessment, Peripheral blood test, Hematoma test
3 · Its place in the literature

Who cites it

294 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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234 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael Galgano1 Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Gentian Toshkezi1 Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Xuecheng Qiu1 Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Thomas Russell1 Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Lawrence Chin1 Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Li-Ru Zhao1 Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY, USA.

Funding

Brain Repair by Hematopoietic Growth Factors in Traumatic Brain InjuryI01RX002125 · VA · SYRACUSE VA MEDICAL CENTER · PI ZHAO, LI-RU · 2016 to 2020
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RRD VA I01 RX002125
6 · The paper itself

Abstract

Traumatic brain injury (TBI) presents in various forms ranging from mild alterations of consciousness to an unrelenting comatose state and death. In the most severe form of TBI, the entirety of the brain is affected by a diffuse type of injury and swelling. Treatment modalities vary extensively based on the severity of the injury and range from daily cognitive therapy sessions to radical surgery such as bilateral decompressive craniectomies. Guidelines have been set forth regarding the optimal management of TBI, but they must be taken in context of the situation and cannot be used in every individual circumstance. In this review article, we have summarized the current status of treatment for TBI in both clinical practice and basic research. We have put forth a brief overview of the various subtypes of traumatic injuries, optimal medical management, and both the noninvasive and invasive monitoring modalities, in addition to the surgical interventions necessary in particular instances. We have overviewed the main achievements in searching for therapeutic strategies of TBI in basic science. We have also discussed the future direction for developing TBI treatment from an experimental perspective.

Indexed as

AnimalsBrain Injuries, TraumaticDisease Models, AnimalHumansNerve Regenerationintracranial hypertensionmanagementtraumatic brain injurytreatment strategies

Identifiers

PMID28933211
PMCPMC5657730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.