Evidence map›Paper›PMID 28933001›Full record

ReviewCurrent HIV/AIDS reports2017

Redefining Aging in HIV Infection Using Phenotypes.

David M Stoff, Karl Goodkin, Dilip Jeste, Maria Marquine

Open access · hybridAbstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Observational
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  12. [Establishment of a vimentin knockout and HIV-1 gp120 transgenic mouse model].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020
    Article
  13. Review
  14. Article
  15. Cognitive Trajectory Phenotypes in Human Immunodeficiency Virus-Infected Patients.Journal of acquired immune deficiency syndromes (1999) · 2019
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

David M StoffAIDS Research Training-Health Disparities and HIV Aging/Comorbidity Research Programs, Division of AIDS Research, National Institute of Mental Health, 5601 Fishers Lane Room 9E25, MSC 9831, Bethesda, MD, 20892, USA. dstoff@mail.nih.gov.
Karl GoodkinEast Tennessee State University, Johnson City, TN, USA.
Dilip JesteUniversity of California San Diego, La Jolla, CA, USA.
Maria MarquineUniversity of California San Diego, La Jolla, CA, USA.
University of California, San Diego · USEast Tennessee State University · USOffice of AIDS Research · US

Funding

Risk and mechanisms of neurocognitive impairment in older HIV-infected HispanicsK23MH105297 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARQUINE, MARIA · 2015 to 2018
$694k
NIMH NIH HHS K23 MH105297
6 · The paper itself

Abstract

purpose of reviewThis article critically reviews the utility of "phenotypes" as behavioral descriptors in aging/HIV research that inform biological underpinnings and treatment development. We adopt a phenotypic redefinition of aging conceptualized within a broader context of HIV infection and of aging. Phenotypes are defined as dimensions of behavior, closely related to fundamental mechanisms, and, thus, may be more informative than chronological age. Primary emphasis in this review is given to comorbid aging and cognitive aging, though other phenotypes (i.e., disability, frailty, accelerated aging, successful aging) are also discussed in relation to comorbid aging and cognitive aging. RECENT

findingsThe main findings that emerged from this review are as follows: (1) the phenotypes, comorbid aging and cognitive aging, are distinct from each other, yet overlapping; (2) associative relationships are the rule in HIV for comorbid and cognitive aging phenotypes; and (3) HIV behavioral interventions for both comorbid aging and cognitive aging have been limited. Three paths for research progress are identified for phenotype-defined aging/HIV research (i.e., clinical and behavioral specification, biological mechanisms, intervention targets), and some important research questions are suggested within each of these research paths.

Indexed as

AgingCognitive DysfunctionComorbidityHIV InfectionsHumansPhenotypeAgingCognitive agingComorbid agingHIVInterventionsPhenotypes

Identifiers

PMID28933001
PMCPMC5614907
OpenAlexW2756186703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.