Evidence map›Paper›PMID 28932967›Full record

ReviewCurrent cardiology reports2017

Psychological Stress, Inflammation, and Coronary Heart Disease.

Petra H Wirtz, Roland von Känel

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current cardiology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06479447 (Patient Outcome Reporting for Timely Assessments of Life With Post-Traumatic Stress Disorder), which is not on this map. Cited by 249 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed, 10 pooled it
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06479447 narecruitingnot on this mapstarted 2024, after this paper: background citation

Patient Outcome Reporting for Timely Assessments of Life With Post-Traumatic Stress Disorder

TypeinterventionalSponsorUniversity of ChicagoRan2024 to 2026Enrolled17,000ConditionsPTSDArmsPORTAL-PTSD
3 · Its place in the literature

Who cites it

249 citing papers in PubMed, 10 syntheses or guidelines pooled it, 519 citations in OpenAlex.

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189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Petra H WirtzBiological Work and Health Psychology, Department of Psychology, University of Konstanz, Universitaetsstrasse 10, 78457, Constance, Baden-Wuerttemberg, Germany. petra.wirtz@uni-konstanz.de.
Roland von KänelDepartment of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
University Hospital of Bern · CHUniversity of Konstanz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewIn this review, we summarize evidence on the risk factor psychological stress in the context of coronary heart disease (CHD) in humans and explore the role of inflammation as a potential underlying mechanism. RECENT

findingsWhile chronic stress increases the risk of incident CHD and poor cardiovascular prognosis, acute emotional stress can trigger acute CHD events in vulnerable patients. Evidence supporting a potential role for inflammation as a promising biological mechanism comes from population-based studies showing associations between chronic stress and increased inflammation. Similarly, experimental studies demonstrate acute stress-induced increases in inflammatory markers and suggest modulatory potential for pharmacological and biobehavioral interventions. So far, studies investigating patients with cardiovascular disease are few and the full sequence of events from stress to inflammation to CHD remains to be established. Psychological stress is an independent CHD risk factor associated with increased inflammation. Although promising, causality needs to be further explored.

Indexed as

BiomarkersCoronary DiseaseHumansInflammationRisk FactorsStress, PsychologicalBiomarkersCoronary heart diseaseC-reactive proteinCytokinesExhaustionInflammationInflammatory stress responseInterleukinInterventionJob burnoutPsychosocial stress

Identifiers

PMID28932967
OpenAlexW2756023329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.