Evidence map›Paper›PMID 28932942›Full record

ArticleAnalytical and bioanalytical chemistry2017

Required hydrophobicity of fluorescent reporters for phosphatidylinositol family of lipid enzymes.

Jarod Waybright, Weigang Huang, Angela Proctor, Xiaoyang Wang, Nancy L Allbritton, Qisheng Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells.Chembiochem : a European journal of chemical biology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jarod WaybrightDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, 301 Pharmacy Lane, Chapel Hill, NC, 27599, USA.
Weigang HuangDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, 301 Pharmacy Lane, Chapel Hill, NC, 27599, USA.
Angela ProctorDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Xiaoyang WangDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, 301 Pharmacy Lane, Chapel Hill, NC, 27599, USA.
Nancy L AllbrittonDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Qisheng ZhangDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, 301 Pharmacy Lane, Chapel Hill, NC, 27599, USA. qszhang@unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Single-Cell Measurement of Lipid Signaling in Colorectal CancerR01CA177993 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ALLBRITTON, NANCY L. · 2014 to 2018
$3.0M
Developing Small Molecule ARFGAP Regulators to Dissect Cell SignalingR01GM086558 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZHANG, QISHENG · 2011 to 2015
$1.4M
NCI NIH HHS R01 CA177993NIGMS NIH HHS R01 GM086558
6 · The paper itself

Abstract

The phosphatidylinositol (PtdIns) family of lipids plays important roles in cell differentiation, proliferation, and migration. Abnormal expression, mutation, or regulation of their metabolic enzymes has been associated with various human diseases such as cancer, diabetes, and bipolar disorder. Recently, fluorescent derivatives have increasingly been used as chemical probes to monitor either lipid localization or enzymatic activity. However, the requirements of a good probe have not been well defined, particularly modifications on the diacylglycerol side chain partly due to challenges in generating PtdIns lipids. We have synthesized a series of fluorescent PtdIns(4,5)P

Indexed as

EnzymesFluorescent DyesHydrophobic and Hydrophilic InteractionsLipidsLiposomesPhosphatidylinositolsEnzymesFluorescent DyesLipidsLiposomesPhosphatidylinositolsChemical cytometryFluorescent reporterLipid enzymePhosphatidylinositol

Identifiers

PMID28932942
PMCPMC5671358
OpenAlexW2754777678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.