Evidence map›Paper›PMID 28932640›Full record

ArticleOncoimmunology

Co-delivery of the NKT agonist α-galactosylceramide and tumor antigens to cross-priming dendritic cells breaks tolerance to self-antigens and promotes antitumor responses.

Reem Ghinnagow, Julie De Meester, Luis Javier Cruz, Caroline Aspord, Stéphanie Corgnac, Elodie Macho-Fernandez, Daphnée Soulard, Josette Fontaine, Laurence Chaperot, Julie Charles and 5 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Allogeneic CAR Invariant Natural Killer T Cells Exert Potent Antitumor Effects through Host CD8 T-Cell Cross-Priming.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  10. Review
  11. Article
  12. Review
  13. Harnessing NKT cells for vaccination.Oxford open immunology · 2021
    Review
  14. BDCA1Clinical & translational immunology · 2020
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Natural killer T cell activation increases iNOSJournal for immunotherapy of cancer · 2019
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Reem GhinnagowUniv. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
Julie De MeesterUniv. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
Luis Javier CruzTranslational Nanobiomaterials and Imaging, Department of radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Caroline AspordInstitute for Advanced Biosciences (IAB), Team Immunobiology and Immunotherapy in Chronic Diseases, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Etablissement Français du Sang-Rhone-Alpes, F-38700 Grenoble, France.
Stéphanie CorgnacINSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, Fac. de médecine - Univ. Paris-Sud, Université Paris-Saclay, 94805, Villejuif, France.
Elodie Macho-FernandezUniv. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
Daphnée SoulardUniv. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
Josette FontaineUniv. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
Laurence ChaperotInstitute for Advanced Biosciences (IAB), Team Immunobiology and Immunotherapy in Chronic Diseases, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Etablissement Français du Sang-Rhone-Alpes, F-38700 Grenoble, France.
Julie CharlesInstitute for Advanced Biosciences (IAB), Team Immunobiology and Immunotherapy in Chronic Diseases, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Etablissement Français du Sang-Rhone-Alpes, F-38700 Grenoble, France.
Fabrice SoncinCentre Hospitalier Universitaire de Lille, F-59000 Lille, France.
Fathia Mami-ChouaibINSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, Fac. de médecine - Univ. Paris-Sud, Université Paris-Saclay, 94805, Villejuif, France.
Joel PlumasInstitute for Advanced Biosciences (IAB), Team Immunobiology and Immunotherapy in Chronic Diseases, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Etablissement Français du Sang-Rhone-Alpes, F-38700 Grenoble, France.
Christelle FaveeuwUniv. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
François TrotteinUniv. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
Centre National de la Recherche Scientifique · FRUniversité Paris-Sud · FRLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccines designed to abrogate the tolerance of tumor self-antigens and amplify cytotoxic CD8

Indexed as

Cancerdendritic cellsnatural killer T cellsself antigenstargetingvaccine

Identifiers

PMID28932640
PMCPMC5599097
OpenAlexW2748089458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.