Evidence map›Paper›PMID 28932627›Full record

ArticleOncoimmunology

Addition of anti-estrogen therapy to anti-HER2 dendritic cell vaccination improves regional nodal immune response and pathologic complete response rate in patients with ER

Lea Lowenfeld, Salman Zaheer, Crystal Oechsle, Megan Fracol, Jashodeep Datta, Shuwen Xu, Elizabeth Fitzpatrick, Robert E Roses, Carla S Fisher, Elizabeth S McDonald and 5 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
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  10. Article
  11. Review
  12. Article
  13. Tribody [(HER2)Frontiers in immunology · 2018
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Lea LowenfeldDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Salman ZaheerDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Crystal OechsleDepartment of Biological Sciences, Kent State University, Kent, OH, USA.
Megan FracolDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Jashodeep DattaDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Shuwen XuDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Elizabeth FitzpatrickDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Robert E RosesDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Carla S FisherDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Elizabeth S McDonaldDepartment of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Paul J ZhangDepartment of Pathology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Angela DeMicheleDivision of Medical Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Rosemarie MickDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.
Gary K KoskiDepartment of Biological Sciences, Kent State University, Kent, OH, USA.
Brian J CzernieckiDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
University of Pennsylvania · USKent State University · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
A HER-2/neu pulsed DC1 vaccine for patients with DCISR01CA096997 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CZERNIECKI, BRIAN JOSEPH · 2003 to 2012
$3.6M
NCI NIH HHS P30 CA016520NCI NIH HHS R01 CA096997
6 · The paper itself

Abstract

HER2-directed therapies are less effective in patients with ER

Indexed as

Breast cancerestrogenHER2immunotherapysentinel lymph nodes

Identifiers

PMID28932627
PMCPMC5599079
OpenAlexW2465355757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.