Evidence map›Paper›PMID 28932623›Full record

ArticleMobile genetic elements2017

Proteomics technique opens new frontiers in mobilome research.

Andrew D Davidson, David A Matthews, Kevin Maringer

Open access · diamondAbstract readComment
In one paragraph

Article in Mobile genetic elements, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Andrew D DavidsonSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
David A MatthewsSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Kevin MaringerDepartment of Microbial Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
University of Bristol · GBUniversity of Surrey · GB

Funding

Medical Research Council G0801973
6 · The paper itself

Abstract

A large proportion of the genome of most eukaryotic organisms consists of highly repetitive mobile genetic elements. The sum of these elements is called the "mobilome," which in eukaryotes is made up mostly of transposons. Transposable elements contribute to disease, evolution, and normal physiology by mediating genetic rearrangement, and through the "domestication" of transposon proteins for cellular functions. Although 'omics studies of mobilome genomes and transcriptomes are common, technical challenges have hampered high-throughput global proteomics analyses of transposons. In a recent paper, we overcame these technical hurdles using a technique called "proteomics informed by transcriptomics" (PIT), and thus published the first unbiased global mobilome-derived proteome for any organism (using cell lines derived from the mosquito

Indexed as

Aedes aegyptiendogenous retrovirusLTR retrotransposonmobilomeproteomics informed by transcriptomics (PIT)repetitive elementtransposon proteomics

Identifiers

PMID28932623
PMCPMC5599074
OpenAlexW2740799118

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.