ReviewInternational journal of nephrology2017
The Role of Sodium Bicarbonate in the Management of Some Toxic Ingestions.
Review in International journal of nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Therapeutic role of erythropoietin in methanol induced optic neuropathy: a systematic review.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Pooled it
- Diphenhydramine, Sodium Bicarbonate, or Combination for Acute Peripheral Vertigo: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Tricyclic Antidepressant Poisoning: A 6-year Retrospective Observational Cross-sectional Analysis of Emergency Department Presentation, Clinical Severity, and Hospital Outcomes in a Tertiary Academic Center.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- Propafenone Overdose Presenting With Brugada Phenocopy, QRS Widening, and Ventricular Fibrillation.JACC. Case reports · 2026Article
- Critical care management of the patient with pharmaceutical poisoning.Intensive care medicine · 2025Review
- Poisoning fromToxins · 2025Article
- Metabolic acidosis in anaesthesia and critical care.BJA education · 2024Review
- Case Reports Study on Methanol Poisoning in King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia.Journal of clinical medicine · 2023Article
- Amitriptyline intoxication in bullfrogs causes widening of QRS complexes in electrocardiogram.The Journal of veterinary medical science · 2023Article
- Electrocardiogram Abnormalities Following Diphenhydramine Ingestion: A Case Report.Journal of education & teaching in emergency medicine · 2023Article
- Evaluation of safety and effectiveness of remdesivir in treating COVID-19 patients after emergency use authorization study.Frontiers in pharmacology · 2023Article
- Bicarbonate Effects on Antibacterial Immunity and Mucus Glycobiology in the Cystic Fibrosis Lung: A Review With Selected Experimental Observations.Infectious microbes & diseases · 2022Article
- Extracorporeal life support as bridge to recovery in yew poisoning: case reports and literature review.ESC heart failure · 2021Review
- The natural history of the concept of antidote.Toxicology reports · 2021Article
- The therapeutic importance of acid-base balance.Biochemical pharmacology · 2021Review
- Comparison of intravenous sodium bicarbonate and sodium chloride combination versus intravenous sodium chloride hydration alone in reducing amphotericin B nephrotoxicity: a randomized clinical trial.Research in pharmaceutical sciences · 2020Article
- Monosodium Glutamate (MSG) Renders Alkalinizing Properties and Its Urinary Metabolic Markers of MSG Consumption in Rats.Biomolecules · 2019Article
- IV Lipid Emulsion Infusion in the Treatment of Severe Diphenhydramine Overdose.The American journal of case reports · 2019Article
- Pharmacological safety ofToxicology reports · 2019Article
- 83-year-old Woman with a Fever and Emesis.Clinical practice and cases in emergency medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse reactions to commonly prescribed medications and to substances of abuse may result in severe toxicity associated with increased morbidity and mortality. According to the Center for Disease Control, in 2013, at least 2113 human fatalities attributed to poisonings occurred in the United States of America. In this article, we review the data regarding the impact of systemic sodium bicarbonate administration in the management of certain poisonings including sodium channel blocker toxicities, salicylate overdose, and ingestion of some toxic alcohols and in various pharmacological toxicities. Based on the available literature and empiric experience, the administration of sodium bicarbonate appears to be beneficial in the management of a patient with the above-mentioned toxidromes. However, most of the available evidence originates from case reports, case series, and expert consensus recommendations. The potential mechanisms of sodium bicarbonate include high sodium load and the development of metabolic alkalosis with resultant decreased tissue penetration of the toxic substance with subsequent increased urinary excretion. While receiving sodium bicarbonate, patients must be monitored for the development of associated side effects including electrolyte abnormalities, the progression of metabolic alkalosis, volume overload, worsening respiratory status, and/or worsening metabolic acidosis. Patients with oliguric/anuric renal failure and advanced decompensated heart failure should not receive sodium bicarbonate.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.