Evidence map›Paper›PMID 28932600›Full record

ArticleSchizophrenia research and treatment2017

Abnormal N400 Semantic Priming Effect May Reflect Psychopathological Processes in Schizophrenia: A Twin Study.

Anuradha Sharma, Heinrich Sauer, Holger Hill, Claudia Kaufmann, Stephan Bender, Matthias Weisbrod

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Anuradha SharmaResearch Group Neurocognition, Department of General Psychiatry, Centre for Psychosocial Medicine, Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-6372-2890
Heinrich SauerDepartment of Psychiatry, University of Jena, Jena, Germany.
Holger HillInstitute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Claudia KaufmannDepartment of General Internal Medicine and Psychosomatics, University of Heidelberg, Heidelberg, Germany.
Stephan BenderDepartment of Child and Adolescent Psychiatry, University Hospital Cologne, Cologne, Germany.
Matthias WeisbrodResearch Group Neurocognition, Department of General Psychiatry, Centre for Psychosocial Medicine, Heidelberg University, Heidelberg, Germany.
Heidelberg University · DEFriedrich Schiller University Jena · DEKarlsruhe Institute of Technology · DEUniversity Hospital Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveActivation of semantic networks is indexed by the N400 effect. We used a twin study design to investigate whether N400 effect abnormalities reflect genetic/trait liability or are related to psychopathological processes in schizophrenia.

methodsWe employed robust linear regression to compare N400 and behavioral priming effects across 36 monozygotic twin pairs (6 pairs concordant for schizophrenia/schizoaffective disorder, 11 discordant pairs, and 19 healthy control pairs) performing a lexical decision task. Moreover, we examined the correlation between Brief Psychiatric Rating Scale (BPRS) score and the N400 effect and the influence of medication status on this effect.

resultsRegression yielded a significant main effect of group on the N400 effect only in the direct priming condition (

conclusionsReduced N400 effect may reflect disease-specific processes in schizophrenia implicating frontotemporal brain network in schizophrenia pathology.

Identifiers

PMID28932600
PMCPMC5592423
OpenAlexW2745445850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.