Evidence map›Paper›PMID 28932547›Full record

ArticleJournal of thoracic disease2017

Does lung cancer surgery cause circulating tumor cells?-A multicenter, prospective study.

Noriyuki Matsutani, Noriyoshi Sawabata, Masafumi Yamaguchi, Tetsukan Woo, Yujin Kudo, Akikazu Kawase, Satoshi Shiono, Hisae Iinuma, Shigeki Morita, Masafumi Kawamura

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Noriyuki MatsutaniDepartment of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
Noriyoshi SawabataDepartment of Thoracic Surgery, Hoshigaoka Medical Center, Osaka, Japan.
Masafumi YamaguchiDepartment of General Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
Tetsukan WooDepartment of Thoracic Surgery, Saiseikai Yokohama City South Hospital, Kanagawa, Japan.
Yujin KudoDepartment of Thoracic Surgery, Tokyo Medical University, Tokyo, Japan.
Akikazu KawaseFirst Department of Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan.
Satoshi ShionoDepartment of Thoracic Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan.
Hisae IinumaDepartment of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
Shigeki MoritaDepartment of Diagnostic Pathology, University Hospital, Teikyo University School of Medicine, Tokyo, Japan.
Masafumi KawamuraDepartment of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
Teikyo University · JPHamamatsu University School of Medicine · JPHoshigaoka Medical Center · JPNational Hospital Organization Kyushu Cancer Center · JPTokyo Medical University · JPYamagata Prefectural Central Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer relapse is caused by residual isolated tumor cells (ITCs) remaining in the body after surgery. It is speculated that surgical manipulation may cause circulating tumor cells (CTCs) which are the origin of ITCs in the body. The occurrence of CTCs in surgical patients with non-small cell lung cancer (NSCLC) has been shown in retrospective observation, but not prospectively, thus we conducted a multicenter prospective study regarding the occurrence of CTCs by surgical manipulation.

methodsPatients with T1b-2N0M0 lung cancer were studied. Blood samples were collected from the peripheral artery in the operating room at both pre- and post-lobectomy to extract CTCs by a size selection method. The CTCs detection rate, pathological findings, and background of each patient were studied.

resultsThe histological diagnosis of 29 patients were adenocarcinoma in 24 patients, squamous cell carcinoma in 3 patients, and other types in 2 patients. The number of pre-CTCs positive patients was 13 and the number of post CTCs positive patients was 17. Among the 16 patients who were pre-CTCs negative, 4 patients showed post CTCs positive, while all pre-CTCs positive patients remained post-CTCs positive.

conclusionsThe likelihood of CTC dislodgement by surgical manipulation is indicated based on the result that CTCs were detected after lung cancer surgery, where there were no cases of pre-CTCs positive and post CTCs negative.

Indexed as

circulating tumor cell (CTC)Lung cancerprospective multicenter studysurgery

Identifiers

PMID28932547
PMCPMC5594144
OpenAlexW2737064921

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.